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Hemagglutinin (HA) (N-Term) antibody

Details for Product No. ABIN1002322, Supplier: Log in to see
Antigen
Epitope
N-Term
20
19
15
14
12
11
10
10
10
9
6
5
4
4
2
2
2
2
2
2
1
Reactivity
Influenza A Virus H5N1
160
32
30
25
12
10
8
7
6
3
2
2
2
1
1
1
1
Host
Rabbit
145
137
11
7
1
Clonality
Polyclonal
Conjugate
Un-conjugated
5
5
5
1
1
1
1
1
1
1
1
Application
ELISA
257
179
10
10
8
5
5
4
4
4
4
3
3
2
2
1
Supplier
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Immunogen Rabbit polyclol Hemagglutinin antibody was raised against a synthetic peptide corresponding to 15 amino acids at the amino terminus of the Hemagglutinin protein (Genbank accession no. AAT76166). Efforts were made to use relatively conserved regions of the viral sequence as the antigen.
Blocking Peptide Blocking peptide for this product available: ABIN1004143
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Hemagglutinin (HA Antibody Abstract)
Background Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals, however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species-jumping ability.
Application Notes Avian influenza hemagglutinin antibody can be used for the detection of the avian influenza hemagglutinin protein from the H5N1 strain of avian influenza A in ELISA. It will detect 10 ng of free peptide at 1 µg/ml. (Optimal dilution should be determined by user.) Other applications are pending.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Background publications Thompson, Shay, Weintraub, Brammer, Cox, Anderson, Fukuda: "Mortality associated with influenza and respiratory syncytial virus in the United States." in: JAMA, Vol. 289, Issue 2, pp. 179-86, 2003

Shortridge, Zhou, Guan, Gao, Ito, Kawaoka, Kodihalli, Krauss, Markwell, Murti, Norwood, Senne, Sims, Takada, Webster: "Characterization of avian H5N1 influenza viruses from poultry in Hong Kong." in: Virology, Vol. 252, Issue 2, pp. 331-42, 1999

Product cited in: Alexander: "A review of avian influenza in different bird species." in: Veterinary microbiology, Vol. 74, Issue 1-2, pp. 3-13, 2000