GDNF Family Receptor alpha 1 (GFRA1) (Internal Region) antibody

Details for Product No. ABIN1002344
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Antigen
Synonyms gdnfr, ret1l, retl1, trnr1, gdnfra, MGC122616, gfr-alpha-1, GFRA1, GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1, GDNFRALPHA, AU042498
Epitope
Internal Region
(7), (4), (4), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(48), (34), (32), (12), (12), (12)
Host
Rabbit
(42), (4), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(31), (22), (20), (10), (7), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 100 µg
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Catalog No. ABIN1002344
514.01 $
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Immunogen Rabbit polyclol GFR-1 antibody was raised against a peptide corresponding to amino acids 369 to 382 of human GFR-1 .
Isotype IgG
Purification Antibody is purified via DEAE-column chromatography.
Alternative Name GDNF Receptor alpha-1
Background Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRa, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGFbeta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRalpha-1 recently. GFRalpha-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRalpha and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.
Application Notes GFRalpha-1 (IN) antibody can be used for detection of GFRalpha-1 by Western blot. (Optimal dilution should be determined by user.) Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.The amino acid sequence of immunogenic peptide is identical to those of mouse and rat and the antibody recognizes GFRalpha-1 from human, mouse and rat origins.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Treanor, Goodman, de Sauvage et al.: "Characterization of a multicomponent receptor for GDNF." in: Nature, Vol. 382, Issue 6586, pp. 80-3, 1996 (PubMed).

Jing, Wen, Yu et al.: "GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF." in: Cell, Vol. 85, Issue 7, pp. 1113-24, 1996 (PubMed).

Sanicola, Hession, Worley et al.: "Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 12, pp. 6238-43, 1997 (PubMed).

Buj-Bello, Adu, Piñón et al.: "Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase." in: Nature, Vol. 387, Issue 6634, pp. 721-4, 1997 (PubMed).

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