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GDNF Family Receptor alpha 2 (GFRA2) (Internal Region) antibody

Details for Product No. ABIN1002346
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Antigen
Synonyms DKFZP459C0228, GFRA2, ntnra, retl2, trnr2, gdnfrb, nrtnr-alpha, gfra2, GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2, Retl2, NTNRALPHA
Epitope
Internal Region
(10), (7), (5), (5), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(54), (30), (30), (13), (13), (12)
Host
Rabbit
(50), (2), (1), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
(46), (18), (10), (10), (4), (3), (3), (2), (1)
Pubmed 4 references available
Quantity 100 µg
Shipping to United States (Change)
Availability Will be delivered in 6 to 7 Business Days
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Catalog No. ABIN1002346
514.01 $
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Immunogen Rabbit polyclol GFR-2 antibody was raised against a peptide corresponding to amino acids 377 to 391 of human GFR-2. The amino acid sequences of immunogenic peptide are identical to those of mouse and rat.
Isotype IgG
Purification Antibody is purified via DEAE-column chromatography.
Alternative Name GDNF Receptor alpha-2
Background Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRalpha, which is a cell surface receptor for NTN. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently. NTNRalpha was also termed GDNFRbeta, Ret ligand 2 (RETL2) or TGFbeta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRalpha-2 recently. GFRalpha-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRalpha-2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.
Application Notes GFRalpha-2 antibody can be used for detection of GFRalpha-2 by Western blot at 1:1000 to 1:2000 dilution. (Optimal dilution should be determined by user.) HeLa whole cell lysate can be used as positive control and a 52 kDa band should be detected. Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far. GFRalpha-2 antibody is human, mouse, and rat reactive.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Kotzbauer, Lampe, Heuckeroth et al.: "Neurturin, a relative of glial-cell-line-derived neurotrophic factor." in: Nature, Vol. 384, Issue 6608, pp. 467-70, 1997 (PubMed).

Baloh, Tansey, Golden et al.: "TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret." in: Neuron, Vol. 18, Issue 5, pp. 793-802, 1997 (PubMed).

Klein, Sherman, Ho et al.: "A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor." in: Nature, Vol. 387, Issue 6634, pp. 717-21, 1997 (PubMed).

Buj-Bello, Adu, Piñón et al.: "Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase." in: Nature, Vol. 387, Issue 6634, pp. 721-4, 1997 (PubMed).

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