TNFRSF14 antibody (Tumor Necrosis Factor Receptor Superfamily, Member 14) (C-Term)

Details for Product anti-TNFRSF14 Antibody No. ABIN1002432, Supplier: Log in to see
Antigen
  • ATAR
  • CD270
  • HVEA
  • HVEM
  • LIGHTR
  • TR2
  • Atar
  • HveA
  • Hvem
  • Tnfrs14
  • tumor necrosis factor receptor superfamily, member 14
  • tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
  • Tnfrsf14
  • TNFRSF14
Alternatives
anti-Human TNFRSF14 antibody for ELISA
Epitope
C-Term
18
16
11
10
9
9
9
9
8
3
3
3
3
2
2
2
2
2
2
1
1
1
Reactivity
Human
167
28
1
1
Host
Rabbit
93
71
15
5
1
Clonality
Polyclonal
Conjugate
This TNFRSF14 antibody is un-conjugated
15
7
7
6
4
4
4
4
4
4
4
4
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
121
75
65
37
20
14
13
10
5
3
2
2
2
1
1
Options
Supplier
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Immunogen TNFRSF14 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human TNFRSF14.
Blocking Peptide Blocking peptide for this product available: ABIN2862480
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Herpes Virus Entry Mediator (TNFRSF14 Antibody Abstract)
Background Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-kappaB and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses.
Pathways Production of Molecular Mediator of Immune Response
Application Notes TNFRSF14 antibody can be used for the detection of TNFRSF14 by Western blot at 1 - 2 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Watts: "TNF/TNFR family members in costimulation of T cell responses." in: Annual review of immunology, Vol. 23, pp. 23-68, 2005 (PubMed).

Background publications Mauri, Ebner, Montgomery, Kochel, Cheung, Yu, Ruben, Murphy, Eisenberg, Cohen, Spear, Ware: "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator." in: Immunity, Vol. 8, Issue 1, pp. 21-30, 1998 (PubMed).

Marsters, Ayres, Skubatch, Gray, Rothe, Ashkenazi et al.: "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB ..." in: The Journal of biological chemistry, Vol. 272, Issue 22, pp. 14029-32, 1997 (PubMed).

Montgomery, Warner, Lum, Spear: "Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family." in: Cell, Vol. 87, Issue 3, pp. 427-36, 1996 (PubMed).