Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (N-Term) antibody

Details for Product No. ABIN1002508
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Antigen
Synonyms
AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IP, IP1, IP2, IPD2, NEMO, ZC2HC9, IKK[g], AI848108, AI851264, AW124339, 1110037D23Rik, Nemo, nemo, fj33c07, wu:fj33c07, zgc:113492, MGC97885, IKBKG, IKBKG_1, IKB ... show more
AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IP, IP1, IP2, IPD2, NEMO, ZC2HC9, IKK[g], AI848108, AI851264, AW124339, 1110037D23Rik, Nemo, nemo, fj33c07, wu:fj33c07, zgc:113492, MGC97885, IKBKG, IKBKG_1, IKBKG_2, CG16910, DmIKK-gamma, DmIKKgamma, Dmel\\CG16910, Dmikkgamma, IKK, IKK[[gamma]], IKKg, IKKgamma, KEY, Kenny, Key, dIKK, dIKK-gamma, dmIKKgamma show less
Epitope
N-Term
(24), (23), (19), (12), (9), (7), (7), (6), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(193), (46), (44), (25), (14), (2), (2)
Host
Rabbit
(172), (23), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Application
ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
(140), (86), (50), (39), (31), (22), (16), (4), (2), (1)
Pubmed 4 references available
Catalog no. ABIN1002508
Quantity 100 µg
Price
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Immunogen Rabbit polyclol IKK( antibody was raised against a peptide (CQYQAPDMDTLQIHVME) corresponding to amino acids 400 to 416 of human IKK( , which are identical to those of mouse homologue .
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name IkB Kinase gamma
Background Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kappaB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-kappaB activity. The IkB kinase (IKKalpha and IKKbeta) phosphorylates IkB and mediates NF-kappaB activation. A novel molecule in the IKK complex was recently identified and termed IKKgamma/NEMO/FIP3/IKKAP1. IKKgamma interacts with IKKbeta and is required for the activation of IKK complex and NF-kappaB by LPS, PMA, TNF, and IL-1 stimulation. FIP3 was also shown to bind to RIP and NIK and to mediate TNF-induced NF-kappaB activation.
Application Notes IKK-gamma antibody can be used for detection of IKK-gamma by Western blot at 0.5 to 1 µg/ml. (Optimal dilution should be determined by user.) A 52 kDa band should be detected. IKK-gamma has no cross response to IKK-alpha or IKK-beta. Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Yamaoka, Courtois, Bessia et al.: "Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation." in: Cell, Vol. 93, Issue 7, pp. 1231-40, 1998 (PubMed).

Rothwarf, Zandi, Natoli et al.: "IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex." in: Nature, Vol. 395, Issue 6699, pp. 297-300, 1998 (PubMed).

Mercurio, Murray, Shevchenko et al.: "IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex." in: Molecular and cellular biology, Vol. 19, Issue 2, pp. 1526-38, 1999 (PubMed).

Li, Kang, Friedman et al.: "Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 3, pp. 1042-7, 1999 (PubMed).

Hosts (172), (23), (1)
Reactivities (193), (46), (44), (25), (14), (2), (2)
Applications (140), (86), (50), (39), (31), (22), (16), (4), (2), (1)
Conjugates (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Epitopes (24), (23), (19), (12), (9), (7), (7), (6), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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