Interferon Regulatory Factor 7 (IRF7) (Internal Region) antibody

Details for Product No. ABIN1002561
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms wu:fl24c03, zgc:66043, zgc:77947, IRF7, irf7, IRF-7H, IRF7A, IRF7B, IRF7C, IRF7H
Epitope
Internal Region
(23), (12), (12), (12), (9), (5), (4), (1), (1), (1), (1), (1)
Reactivity
Human
(100), (45), (44), (26), (26), (13)
Host
Rabbit
(79), (21)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(75), (30), (20), (20), (15), (3), (3), (1), (1), (1)
Pubmed 4 references available
Quantity 100 μg
Shipping to United States (Change)
Availability Will be delivered in 6 to 7 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1002561
514.01 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen IRF7 antibody was raised against a peptide corresponding to 14 amino acids near the center of human IRF7.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Interferon Regulatory Factor 7
Background Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.
Application Notes This antibody can be used for detection of IRF7 by Western blot at 1 myg/ml. Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far. This antibody is human reactive.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002 (PubMed).

Nishiya, DeFranco: "Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors." in: The Journal of biological chemistry, Vol. 279, Issue 18, pp. 19008-17, 2004 (PubMed).

Wagner: "The immunobiology of the TLR9 subfamily." in: Trends in immunology, Vol. 25, Issue 7, pp. 381-6, 2004 (PubMed).

Fantuzzi: "Adipose tissue, adipokines, and inflammation." in: The Journal of allergy and clinical immunology, Vol. 115, Issue 5, pp. 911-9; quiz 920, 2005 (PubMed).

Validation Images
Did you look for something else?
back to top