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Interferon Regulatory Factor 8 (IRF8) antibody

Details for Product No. ABIN1002562, Supplier: Login to see New
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Synonyms zgc:92252, IRF8, MGC140338, DKFZp469B0320, H-ICSBP, ICSBP, ICSBP1, IRF-8, icsbp1, AI893568, Icsbp1, Myls
Human, Mouse (Murine), Rat (Rattus)
(98), (37), (21), (5), (5), (4), (1), (1), (1), (1), (1), (1)
(75), (21), (6)
(2), (2), (1), (1), (1), (1), (1)
ELISA, Western Blotting (WB)
(91), (45), (22), (15), (11), (5), (4), (4), (2), (1), (1)
Pubmed 4 references available
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Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 15 to 19 Business Days
Immunogen Rabbit polyclol IRF8 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy-terminus of human IRF8 (GenBank accession no. NP_002154). IRF8 antibody is human, mouse, and rat reactive.
Blocking Peptide Blocking peptide for this product available: ABIN1004375
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Interferon Regulatory Factor 8 (IRF8 Antibody Abstract)
Background Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Unlike IRF3, IRF8 appears to act as a negative regulator of IFN-induced genes in most cases, but IRF8 mediates activation of NF-kappaB by the toll-like receptor 9 (TLR9) after stimulation by unmethylated CpG DNA in dendritic cells. Finally, it has been shown that IRF8 decreases bcl-2 expression and thus may play a role in chronic myelogenous leukemia.
Application Notes IRF8 antibody can be used for detection of IRF8 by Western blot at 1 - 2 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Malmgaard: "Induction and regulation of IFNs during viral infections." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 24, Issue 8, pp. 439-54, 2004 (PubMed).

Tsujimura, Tamura, Kong et al.: "Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 11, pp. 6820-7, 2004 (PubMed).

Nelson, Marks, Driggers et al.: "Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription." in: Molecular and cellular biology, Vol. 13, Issue 1, pp. 588-99, 1993 (PubMed).

Background publications Weisz, Marx, Sharf et al.: "Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes." in: The Journal of biological chemistry, Vol. 267, Issue 35, pp. 25589-96, 1993 (PubMed).

Catalog No. ABIN1002562
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