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IL21 antibody (Interleukin 21) (Internal Region)

Details for Product anti-IL21 Antibody No. ABIN1002621, Supplier: Login to see
Antigen
  • IL-21
  • Za11
Alternatives
anti-Human IL21 antibody for ELISA
Epitope
Internal Region
26
14
13
12
7
7
5
4
4
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
164
67
20
8
5
5
Host
Rabbit
159
31
11
8
6
Clonality
Polyclonal
Conjugate
This IL21 antibody is un-conjugated
18
13
9
8
6
6
4
3
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
130
125
21
17
16
16
11
8
7
7
5
5
4
3
2
2
1
1
1
1
1
Supplier
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Immunogen Rabbit polyclol IL-21 antibody was raised against a synthetic peptide corresponding to 15 amino acids near the center of human IL-21 precursor .
Blocking Peptide Blocking peptide for this product available: ABIN1004025
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Interleukin 21 (IL21 Antibody Abstract)
Background A novel cytokine was recently identified in human and mouse and designated IL-21, which has significant homology to IL-2, IL-4, and IL-15. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21 is expressed in activated T cells, and HL-60 and THP-1 cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.
Pathways JAK-STAT Signaling
Application Notes IL-21 antibody can be used for detection of IL-21 by Western blot at 0.5 to 1 µg/ml. (Optimal dilution should be determined by user.)An approximately 18 kDa band can be detected. Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Asao, Okuyama, Kumaki et al.: "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 1, pp. 1-5, 2001 (PubMed).

Parrish-Novak, Dillon, Nelson et al.: "Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. ..." in: Nature, Vol. 408, Issue 6808, pp. 57-63, 2000 (PubMed).

Background publications Ozaki, Kikly, Michalovich et al.: "Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 21, pp. 11439-44, 2000 (PubMed).