Interleukin 21 Receptor (IL21R) (Extracellular Domain) antibody

Details for Product No. ABIN1002623
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Antigen
Synonyms CD360, NILR, IL21R, il-21ra.a
Epitope
Extracellular Domain
(7), (5), (5), (3), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(54), (46), (25), (12)
Host
Rabbit
(52), (18), (3), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (6), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(43), (25), (20), (13), (10), (7), (2), (2)
Pubmed 4 references available
Catalog no. ABIN1002623
Quantity 100 µg
Price
514.01 $   Plus shipping costs $45.00
Shipping to United States (Change)
Availability Will be delivered in 6 to 7 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Rabbit polyclol IL-21R antibody was raised against a synthetic peptide (NITDQSGNYSQECGS) corresponding to amino acids 97 to 111 of human IL-21R precursor .
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Interleukin 21 Receptor
Background A novel cytokine related to IL-2 and IL-15 was recently identified and designated IL-21. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling. Both IL-21R and the gc are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.
Application Notes IL-21 receptor antibody can be used for detection of IL-21 receptor by Western blot at 0.5 to 1 µg/ml. (Optimal dilution should be determined by user.) An approximately 60 kDa band can be detected. Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Ozaki, Kikly, Michalovich et al.: "Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 21, pp. 11439-44, 2000 (PubMed).

Parrish-Novak, Dillon, Nelson et al.: "Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function." in: Nature, Vol. 408, Issue 6808, pp. 57-63, 2000 (PubMed).

Vosshenrich, Di Santo: "Cytokines: IL-21 joins the gamma(c)-dependent network?" in: Current biology : CB, Vol. 11, Issue 5, pp. R175-7, 2001 (PubMed).

Asao, Okuyama, Kumaki et al.: "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 1, pp. 1-5, 2001 (PubMed).

Hosts (52), (18), (3), (2)
Reactivities (54), (46), (25), (12)
Applications (43), (25), (20), (13), (10), (7), (2), (2)
Conjugates (7), (6), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (5), (5), (3), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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