You are viewing an incomplete version of our website. Please click to reload the website as full version.

IL21 Receptor antibody (Interleukin 21 Receptor) (N-Term)

Details for Product anti-IL21R Antibody No. ABIN1002624, Supplier: Log in to see
Antigen
  • IL21R
  • il-21ra.a
  • CD360
  • NILR
Alternatives
anti-Human IL21 Receptor antibody for Western Blotting
Epitope
N-Term
13
12
11
7
4
4
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
81
45
27
2
Host
Rabbit
66
16
13
6
Clonality
Polyclonal
Conjugate
This IL21 Receptor antibody is un-conjugated
8
6
4
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
47
35
21
19
11
11
4
3
2
2
2
1
1
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Showcase your results, aid the scientific community, and receive a full refund.

Contribute a validation

Learn more

Immunogen Rabbit polyclol IL-21R antibody was raised against a synthetic peptide (CPDLVCYTDYLQT) corresponding to amino acids 20 to 32 of human IL-21R precursor .
Blocking Peptide Blocking peptide for this product available: ABIN1004147
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Interleukin 21 Receptor (IL21R Antibody Abstract)
Background A novel cytokine related to IL2 and IL15 was recently identified and designated IL-21 . The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling. Both IL-21R and the gc are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.
Pathways JAK-STAT Signaling
Application Notes IL-21 receptor antibody can be used for detection of IL-21 receptor by Western blot at 0.5 to 1 µg/ml. (Optimal dilution should be determined by user.) An approximately 60 kDa band can be detected. Antibody can also be used for ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Asao, Okuyama, Kumaki et al.: "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 1, pp. 1-5, 2001 (PubMed).

Vosshenrich, Di Santo: "Cytokines: IL-21 joins the gamma(c)-dependent network?" in: Current biology : CB, Vol. 11, Issue 5, pp. R175-7, 2001 (PubMed).

Parrish-Novak, Dillon, Nelson et al.: "Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. ..." in: Nature, Vol. 408, Issue 6808, pp. 57-63, 2000 (PubMed).

Background publications Ozaki, Kikly, Michalovich et al.: "Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 21, pp. 11439-44, 2000 (PubMed).