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Interleukin 22 Receptor (IL22R) (N-Term) antibody

Details for Product No. ABIN1002628
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Antigen
Epitope
N-Term
(2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(11), (1)
Host
Rabbit
(11)
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
(8), (5), (2), (1), (1)
Pubmed 4 references available
Quantity 100 µg
Shipping to United States (Change)
Availability Will be delivered in 6 to 7 Business Days
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1002628
514.01 $
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Immunogen Rabbit polyclol IL-22R antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human IL-22R precursor .
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Interleukin 22 Receptor
Background A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor b chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-a 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.
Application Notes IL-22 receptor antibody can be used for detection of IL-22 receptor by Western blot at 0.5 to 1 µg/ml. (Optimal dilution should be determined by user.) An approximately 62 kDa band can be detected. Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Dumoutier, Louahed, Renauld: "Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 4, pp. 1814-9, 2000 (PubMed).

Xie, Aggarwal, Ho et al.: "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R." in: The Journal of biological chemistry, Vol. 275, Issue 40, pp. 31335-9, 2000 (PubMed).

Dumoutier, Van Roost, Colau et al.: "Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 18, pp. 10144-9, 2000 (PubMed).

Kotenko, Izotova, Mirochnitchenko et al.: "Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes." in: The Journal of biological chemistry, Vol. 276, Issue 4, pp. 2725-32, 2001 (PubMed).

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