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Details for Product No. ABIN1002629

Interleukin 23 (IL23) (C-Term) antibody

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Antigen
Synonyms FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
Pubmed 4 references available
Catalog no. ABIN1002629
Quantity 100 µg
Price
514.01 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 7 Business Days
Immunogen IL-23 antibody was raised against a 16 amino acid peptide from near the amino terminus of human IL-23.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Interleukin 23
Background Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes. Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-alpha from activated T cells, and can stimulate macrophages to produce TNF-alpha and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.
Application Notes This antibody can be used for the detection of IL-23 by Western blot at 2 - 4 myg/ml. Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far. This antibody is human and mouse reactive.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Oppmann, Lesley, Blom et al.: "Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12." in: Immunity, Vol. 13, Issue 5, pp. 715-25, 2001 (PubMed).

Pirhonen, Matikainen, Julkunen: "Regulation of virus-induced IL-12 and IL-23 expression in human macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 10, pp. 5673-8, 2002 (PubMed).

Sheibanie, Tadmori, Jing et al.: "Prostaglandin E2 induces IL-23 production in bone marrow-derived dendritic cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 18, Issue 11, pp. 1318-20, 2004 (PubMed).

Hunter: "New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions." in: Nature reviews. Immunology, Vol. 5, Issue 7, pp. 521-31, 2005 (PubMed).

Alternatives for antigen "Interleukin 23 (IL23)", type "Antibodies"
Hosts (4)
Reactivities (3)
Applications (4), (1)
Epitopes (3), (1)
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