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Details for Product No. ABIN1002638

Interleukin 32 (IL32) (Internal Region) antibody

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Antigen
Synonyms NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd, IL-32beta, IL-32alpha, IL-32delta, IL-32gamma
Epitope
»Alternatives Internal Region
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN1002638
Quantity 100 µg
Price
514.01 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 7 Business Days
Immunogen IL-32 antibody was raised against a 16 amino acid peptide from near the center of human IL-32 (Genbank accession No. AAH09401).
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Interleukin 32
Background Interleukin-32 (IL-32) was initially identified as a transcript (NK4) that is selectively expressed in lymphocytes and NK cells and whose expression is increased following activation by IL-2. It was later re-isolated from an IL-18-treated lung carcinoma cell line and re-named IL-32. IL-32 is unusual in that it does not share sequence homology with known cytokine families and is highly expressed in immune tissues, existing in at least four differentially spliced isoforms. Because treatment of human monocytic and mouse macrophage cells with IL-32 induces several proinflammatory cytokines such as TNF-alpha, IL-8 and MIP-2, and because it is also induced in human peripheral lymphocyte cells after mitogen stimulation and in epithelial cells by IFNgamma, it has been suggested that IL-32 may play a role in autoimmune and inflammatory diseases such as rheumatoid arthritis.
Application Notes IL-32 antibody can be used for the detection of IL-32 by Western blot at 2.5 – 5 µg/ml. (Optimal dilution should be determined by user.) This antibody detects the largest isoform of IL-32. Antibody can also be used for ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Dahl, Schall, He et al.: "Identification of a novel gene expressed in activated natural killer cells and T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 2, pp. 597-603, 1992 (PubMed).

Kim, Han, Azam et al.: "Interleukin-32: a cytokine and inducer of TNFalpha." in: Immunity, Vol. 22, Issue 1, pp. 131-42, 2005 (PubMed).

Cagnard, Letourneur, Essabbani et al.: "Interleukin-32, CCL2, PF4F1 and GFD10 are the only cytokine/chemokine genes differentially expressed by in vitro cultured rheumatoid and osteoarthritis fibroblast-like synoviocytes." in: European cytokine network, Vol. 16, Issue 4, pp. 289-92, 2006 (PubMed).

Alternatives for antigen "Interleukin 32 (IL32)", type "Antibodies"
Hosts (73), (11), (1)
Reactivities (89), (27), (1)
Applications (67), (37), (17), (17), (10), (4), (3), (3), (2), (1), (1)
Conjugates (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (21), (5), (5), (4), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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