Leucine-Rich Repeat LGI Family, Member 3 (LGI3) (Internal Region) antibody

Details for Product No. ABIN1002726, Supplier: Log in to see
Antigen
  • si:ch211-198o12.2
  • LGIL4
  • AI841179
  • AW049851
  • leucine-rich repeat LGI family, member 3
  • LGI3
  • lgi3
  • Lgi3
Epitope
Internal Region
17
14
11
2
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
57
30
30
1
1
1
1
Host
Rabbit
56
1
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
43
25
13
7
6
3
2
2
1
1
1
Options
Supplier
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Immunogen LGI3 antibody was raised in rabbits against a 12 amino acid peptide from near the center of human LGI3.
Blocking Peptide Blocking peptide for this product available: ABIN1003956
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name LGI3 (LGI3 Antibody Abstract)
Background The leucine-rich, glioma inactivated gene 3 (LGI3) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI3 have not been found to be associated with ADTLE. LGI3 expression is induced in rat astrocyte cultures by the amyloid beta (Ab) peptide and accumulated on neuronal plasma membranes of aged monkey brains and co-localized with Ab. Two isoforms of LGI3 are known to exist, this LGI3 antibody will recognize both. This LGI3 antibody is predicted to be specific to LGI3 and not recognize other LGI proteins. The observed higher molecular weight band may represent a post-translationally modified form of LGI3.
Application Notes LGI3 antibody can be used for the detection of LGI3 by Western blot at 1 – 2 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Kimura, Ishii, Suzaki, Negishi, Kyuwa, Yoshikawa: "Abeta upregulates and colocalizes with LGI3 in cultured rat astrocytes." in: Cellular and molecular neurobiology, Vol. 27, Issue 3, pp. 335-50, 2007 (PubMed).

Gu, Gibert, Wirth, Elischer, Bloch, Meyer, Steinlein, Begemann: "Using gene-history and expression analyses to assess the involvement of LGI genes in human disorders." in: Molecular biology and evolution, Vol. 22, Issue 11, pp. 2209-16, 2005 (PubMed).

Berkovic, Izzillo, McMahon, Harkin, McIntosh, Phillips, Briellmann, Wallace, Mazarib, Neufeld, Korczyn, Scheffer, Mulley: "LGI1 mutations in temporal lobe epilepsies." in: Neurology, Vol. 62, Issue 7, pp. 1115-9, 2004 (PubMed).

Chernova, Somerville, Cowell: "A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors." in: Oncogene, Vol. 17, Issue 22, pp. 2873-81, 1999 (PubMed).

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