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Details for Product No. ABIN1002729

DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (C-Term) antibody

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Antigen
Synonyms B430001I08Rik, D11Lgp2e, LPG2, Lgp2, RLR-3, RGD1310093, LGP2, D11LGP2, D11lgp2e, MGC82787, DHX58, lgp2
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN1002729
Quantity 100 µg
Price
514.01 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 6 to 7 Business Days
Immunogen LGP2 antibody was raised in rabbits against a 12 amino acid peptide from near the carboxy terminus of human LGP2.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name LGP2
Background Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling. At least four isoforms of LGP2 are known to exist.
Application Notes LGP2 antibody can be used for detection of LGP2 by Western blot at 1 – 2 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Yoneyama, Kikuchi, Natsukawa et al.: "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses." in: Nature immunology, Vol. 5, Issue 7, pp. 730-7, 2004 (PubMed).

Iwasaki, Medzhitov: "Toll-like receptor control of the adaptive immune responses." in: Nature immunology, Vol. 5, Issue 10, pp. 987-95, 2004 (PubMed).

Andrejeva, Childs, Young et al.: "The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 49, pp. 17264-9, 2004 (PubMed).

Akira, Uematsu, Takeuchi: "Pathogen recognition and innate immunity." in: Cell, Vol. 124, Issue 4, pp. 783-801, 2006 (PubMed).

Alternatives for antigen "DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58)", type "Antibodies"
Hosts (51), (6), (2)
Reactivities (53), (26), (25), (1), (1), (1), (1), (1), (1)
Applications (55), (36), (5), (4), (3), (1)
Epitopes (16), (14), (4), (3), (3), (2), (2), (1)
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