Did you know that you can buy products from over 140 different suppliers from us?

Lysine (K)-Specific Demethylase 1A (KDM1A) (Internal Region) antibody

Details for Product No. ABIN1002762
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms
AOF2, BHC110, KDM1, LSD1, 1810043O07Rik, AA408884, Aof2, D4Ertd478e, Kdm1, Lsd1, mKIAA0601, RGD1562975, aof2, kdm1, wu:fb82e06, wu:fc51a02, wu:fj36a05, wu:fj66b06, ARABIDOPSIS LYSINE-SPECIFIC HISTONE  ... show more
AOF2, BHC110, KDM1, LSD1, 1810043O07Rik, AA408884, Aof2, D4Ertd478e, Kdm1, Lsd1, mKIAA0601, RGD1562975, aof2, kdm1, wu:fb82e06, wu:fc51a02, wu:fj36a05, wu:fj66b06, ARABIDOPSIS LYSINE-SPECIFIC HISTONE DEMETHYLASE, ATLSD1, ATSWP1, F23N19.21, F23N19_21, LSD1-like 1, LYSINE-SPECIFIC HISTONE DEMETHYLASE, SWP1, KDM1A, DKFZp459N2450, lsd1, xLSD1 show less
Epitope
Internal Region
(16), (6), (5), (5), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(134), (69), (59), (33), (26), (26), (24), (14), (3), (2), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(105), (32), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(115), (54), (41), (27), (20), (16), (7), (4), (4), (4), (3), (1), (1)
Pubmed 4 references available
Quantity 100 µg
Shipping to United States (Change)
Availability Will be delivered in 6 to 7 Business Days
Catalog No. ABIN1002762
514.01 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen LSD1 antibody was raised against a 16 amino acid peptide from near the center of human LSD1.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Lysine Specific Histone Demethylase 1
Background Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction. Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription. LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation. Experiments have shown that CoREST, a SANT domain-containing corepressor acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein, inhibits CoREST/LSD1 activity in vitro. LSD1-mediated histone demethylation thus may have significant effects on gene expression.
Application Notes LSD1 antibody can be used for the detection of LSD1 by Western blot at 1 – 2 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Kouzarides: "Histone methylation in transcriptional control." in: Current opinion in genetics & development, Vol. 12, Issue 2, pp. 198-209, 2002 (PubMed).

Nakamura, Mori, Tada et al.: "ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation." in: Molecular cell, Vol. 10, Issue 5, pp. 1119-28, 2002 (PubMed).

Shi, Lan, Matson et al.: "Histone demethylation mediated by the nuclear amine oxidase homolog LSD1." in: Cell, Vol. 119, Issue 7, pp. 941-53, 2004 (PubMed).

Shi, Matson, Lan et al.: "Regulation of LSD1 histone demethylase activity by its associated factors." in: Molecular cell, Vol. 19, Issue 6, pp. 857-64, 2005 (PubMed).

Hosts (105), (32), (1)
Reactivities (134), (69), (59), (33), (26), (26), (24), (14), (3), (2), (1), (1), (1), (1), (1), (1)
Applications (115), (54), (41), (27), (20), (16), (7), (4), (4), (4), (3), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (16), (6), (5), (5), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1002762
514.01 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
back to top