Nerve Growth Factor Receptor (NGFR) antibody

Details for Product No. ABIN1002888
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Antigen
Synonyms ngfr, wu:fb38c02, wu:fc10h01, CD271, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR, LNGFR, RNNGFRR, Tnfrsf16, p75, NRH1b, fullback, nrh1, p75ntr, tnfrsf16, p75NGFR
Reactivity
Human, Mouse (Murine)
(148), (74), (72), (29), (14), (13), (13), (8), (7), (5), (3), (3), (1), (1), (1), (1)
Host
Rabbit
(107), (51), (11), (4), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(10), (5), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application
ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
(126), (57), (46), (41), (37), (31), (26), (20), (20), (19), (10), (6), (4), (4), (1), (1), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 100 μg
Shipping to United States (Change)
Availability Will be delivered in 6 to 7 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1002888
514.01 $
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  • +1 404 474 4654
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Immunogen Rabbit polyclol NGFR antibody was raised against purified recombint human NGFR (Genbank accession NP_002498).
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Nerve Growth Factor Receptor
Background The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kappaB and various mitogen-activated protein kinases. Nerve growth factor receptor (NGFR) was one of the earliest characterized members of this family. Also known as the low-affinity receptor p75NTR, this receptor is involved in several diverse functions such as apoptosis, neurite outgrowth during development, and myelination. Its ligands include NGF, brain-derived neurotrophic factor (BDNF), NT3, and NT4. NGFR can also associate with other NGF receptors such as Trk through the cytosolic and transmembrane domains and thus can function as a co-receptor that refines Trk affinity and specificity for neurotrophins. Finally, upon binding of various neurotrophins, NGFR associates with tumor necrosis factor receptor-6 (TRAF6), suggesting that it can potentially function as a signal transducer for NGF signals through NGFR.
Application Notes NGFR antibody can be used for the detection of NGFR by Western blot at 1 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Johnson, Lanahan, Buck et al.: "Expression and structure of the human NGF receptor." in: Cell, Vol. 47, Issue 4, pp. 545-54, 1986 (PubMed).

Gaur, Aggarwal: "Regulation of proliferation, survival and apoptosis by members of the TNF superfamily." in: Biochemical pharmacology, Vol. 66, Issue 8, pp. 1403-8, 2003 (PubMed).

Gentry, Barker, Carter: "The p75 neurotrophin receptor: multiple interactors and numerous functions." in: Progress in brain research, Vol. 146, pp. 25-39, 2003 (PubMed).

Nykjaer, Willnow, Petersen: "p75NTR--live or let die." in: Current opinion in neurobiology, Vol. 15, Issue 1, pp. 49-57, 2005 (PubMed).

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