NF-kB Inducing Kinase (C-Term) antibody

Details for Product No. ABIN1002908
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Antigen
Epitope
C-Term
Reactivity
Human
Host
Rabbit
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB)
Pubmed 4 references available
Quantity 100 μg
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Catalog No. ABIN1002908
514.01 $
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Immunogen Rabbit polyclol NIK antibody was raised against a peptide corresponding to amino acids 931 to 947 of human NIK .
Isotype IgG
Purification Antibody is purified via DEAE-column chromatography.
Background Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha, LPS and mitogens. A serine/threonine protein kinase which mediates NF-kappaB activation by IL-1, TNFalpha and CD95 was identified recently and designated NIK (for NF-kappaB inducing kinase) . NIK is an activator of IkappaB kinase alpha and beta (IKKalpha and IKKbeta). Therefore, NIK is a key molecule in the NF-kappaB signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products.
Application Notes NIK antibody is human-specific and can be used for detection of NIK by Western blot. (Optimal antibody dilution should be determined by user.) 293 cell lysate can be used as positive control. Antibody can also be used for ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Malinin, Boldin, Kovalenko et al.: "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1." in: Nature, Vol. 385, Issue 6616, pp. 540-4, 1997 (PubMed).

Régnier, Song, Gao et al.: "Identification and characterization of an IkappaB kinase." in: Cell, Vol. 90, Issue 2, pp. 373-83, 1997 (PubMed).

Woronicz, Gao, Cao et al.: "IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK." in: Science (New York, N.Y.), Vol. 278, Issue 5339, pp. 866-9, 1997 (PubMed).

Ling, Cao, Goeddel: "NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 7, pp. 3792-7, 1998 (PubMed).

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