Reticulon 4 (RTN4) (Internal Region) antibody

Details for Product No. ABIN1002922
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Antigen
Synonyms
RTN4-Cw, DKFZp459C0314, NOGO, NOGO-A, reticulon-4, ASY, NI220/250, NOGOC, NSP, NSP-CL, Nbla00271, Nbla10545, Nogo-B, Nogo-C, RTN-X, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C, 1110020G17Rik, AA407876, AA409940, ... show more
RTN4-Cw, DKFZp459C0314, NOGO, NOGO-A, reticulon-4, ASY, NI220/250, NOGOC, NSP, NSP-CL, Nbla00271, Nbla10545, Nogo-B, Nogo-C, RTN-X, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C, 1110020G17Rik, AA407876, AA409940, AA960376, C130026I10Rik, NgA, Nogo-A, mKIAA0886, mKIAA4153, NI-250, Nogo, Vp20, r, rat N, rat NogoA, NGR, NOGOR, NgR, NgR1, Nogor show less
Epitope
Internal Region
(16), (15), (12), (8), (6), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(91), (75), (74), (3), (2), (2), (1)
Host
Rabbit
(99), (7), (4), (2), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(88), (49), (34), (28), (20), (6), (5), (1)
Pubmed 4 references available
Quantity 100 µg
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Catalog No. ABIN1002922
514.01 $
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Immunogen NogoA antibody was raised in rabbits against a 19 amino acid peptide from near the center of human NogoA.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name NogoA
Background NogoA is a member of a family of integral membrane proteins termed reticulons that are thought to be involved in numerous disorders including neurodegenerative diseases. Reticulon proteins are known to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor. It is highly expressed in oligodendrocytes in the white matter of the CNS, blocking its activity with antibodies or other factors results in improved axon regrowth and functional recovery in experimental CNS lesion models. NogoA has also been suggested to play a role in neurodegenerative diseases such as Amyotrophic lateral sclerosis, in which case NogoA is found at elevated levels in postmortem muscular samples, and multiple sclerosis (MS), in which case autoantibodies to NogoA have been found in serum and cerebrospinal fluid in MS patients. Despite its predicted molecular weight, NogoA typically migrates at 180kDa in an SDS-PAGE. At least five isoforms of Nogo are known to exist, this antibody is specific for NogoA and NogoE.
Application Notes NogoA antibody can be used for detection of NogoA by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Chen, Huber, van der Haar et al.: "Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1." in: Nature, Vol. 403, Issue 6768, pp. 434-9, 2000 (PubMed).

Dupuis, Gonzalez de Aguilar, di Scala et al.: "Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis." in: Neurobiology of disease, Vol. 10, Issue 3, pp. 358-65, 2002 (PubMed).

Yan, Shi, Hu et al.: "Reticulon proteins: emerging players in neurodegenerative diseases." in: Cellular and molecular life sciences : CMLS, Vol. 63, Issue 7-8, pp. 877-89, 2006 (PubMed).

Schweigreiter, Bandtlow: "Nogo in the injured spinal cord." in: Journal of neurotrauma, Vol. 23, Issue 3-4, pp. 384-96, 2006 (PubMed).

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