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Reticulon 4 (RTN4) (N-Term) antibody

Details for Product No. ABIN1002923, Supplier: Login to see
Antigen
  • RTN4-Cw
  • DKFZp459C0314
  • NOGO
  • NOGO-A
  • reticulon-4
  • ASY
  • NI220/250
  • NOGOC
  • NSP
  • NSP-CL
  • Nbla00271
  • Nbla10545
  • Nogo-B
  • Nogo-C
  • RTN-X
  • RTN4-A
  • RTN4-B1
  • RTN4-B2
  • RTN4-C
  • 1110020G17Rik
  • AA407876
  • AA409940
  • AA960376
  • C130026I10Rik
  • NgA
  • Nogo-A
  • mKIAA0886
  • mKIAA4153
  • NI-250
  • Nogo
  • Vp20
  • r
  • rat N
  • rat NogoA
  • NGR
  • NOGOR
  • NgR
  • NgR1
  • Nogor
Alternatives
anti-Human Reticulon 4 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
N-Term
18
17
16
13
12
5
4
4
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
122
85
84
5
4
3
3
2
2
1
1
Host
Rabbit
127
11
5
3
2
Clonality
Polyclonal
Conjugate
Un-conjugated
5
3
2
2
2
2
2
2
2
2
2
2
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
112
56
48
36
22
6
6
5
4
2
1
Supplier
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Immunogen NogoA antibody was raised in rabbits against a 23 amino acid peptide from near the amino terminus of human NogoA.
Blocking Peptide Blocking peptide for this product available: ABIN1004166
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name NogoA (RTN4 Antibody Abstract)
Background NogoA is a member of a family of integral membrane proteins termed reticulons that are thought to be involved in numerous disorders including neurodegenerative diseases. Reticulon proteins are known to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor. It is highly expressed in oligodendrocytes in the white matter of the CNS, blocking its activity with antibodies or other factors results in improved axon regrowth and functional recovery in experimental CNS lesion models. NogoA has also been suggested to play a role in neurodegenerative diseases such as Amyotrophic lateral sclerosis, in which case NogoA is found at elevated levels in postmortem muscular samples, and multiple sclerosis (MS), in which case autoantibodies to NogoA have been found in serum and cerebrospinal fluid in MS patients. Despite its predicted molecular weight, NogoA typically migrates at 180kDa in an SDS-PAGE. At least five isoforms of Nogo are known to exist, this antibody is specific for NogoA.
Pathways Neurotrophin Signaling Pathway
Application Notes NogoA antibody can be used for detection of NogoA by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Schweigreiter, Bandtlow: "Nogo in the injured spinal cord." in: Journal of neurotrauma, Vol. 23, Issue 3-4, pp. 384-96, 2006 (PubMed).

Yan, Shi, Hu et al.: "Reticulon proteins: emerging players in neurodegenerative diseases." in: Cellular and molecular life sciences : CMLS, Vol. 63, Issue 7-8, pp. 877-89, 2006 (PubMed).

Dupuis, Gonzalez de Aguilar, di Scala et al.: "Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis." in: Neurobiology of disease, Vol. 10, Issue 3, pp. 358-65, 2002 (PubMed).

Chen, Huber, van der Haar et al.: "Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1." in: Nature, Vol. 403, Issue 6768, pp. 434-9, 2000 (PubMed).