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Details for Product No. ABIN1002924

Nonstructural Protein 1 antibody

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Antigen
Reactivity
»Alternatives Virus
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA
Pubmed 4 references available
Catalog no. ABIN1002924
Quantity 100 µg
Price
514.01 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 7 Business Days
Immunogen NS1 antibody was raised against a synthetic peptide corresponding to 14 amino acids at the carboxy terminus of the NS1 protein. Efforts were made to use relatively conserved regions of the viral sequence as the antigen.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Background Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals, however, it is in birds that all subtypes, including the so-called “avian flu” or H5N1, can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. One of the less studied proteins encoded by, but not incorporated in, the influenza virus is the nonstructural protein (NS) 1. NS1 counters cellular antiviral activities and acts as a virulence factor. It can bind to double-stranded RNA and sequester it from 2’-5’ OAS, preventing the activation of the RNAse L, which normally acts to degrade RNA and prevent virus replication. NS1 also binds to and inhibits the anti-viral protein kinase PKR.
Application Notes Avian Influenza Nonstructural Protein 1 antibody can be used for the detection of the avian influenza nonstructural protein 1 protein from influenza A in ELISA. Other applications are pending.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Alexander: "A review of avian influenza in different bird species." in: Veterinary microbiology, Vol. 74, Issue 1-2, pp. 3-13, 2000 (PubMed).

Thompson, Shay, Weintraub et al.: "Mortality associated with influenza and respiratory syncytial virus in the United States." in: JAMA : the journal of the American Medical Association, Vol. 289, Issue 2, pp. 179-86, 2003 (PubMed).

Krug, Yuan, Noah et al.: "Intracellular warfare between human influenza viruses and human cells: the roles of the viral NS1 protein." in: Virology, Vol. 309, Issue 2, pp. 181-9, 2003 (PubMed).

Min, Krug: "The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 18, pp. 7100-5, 2006 (PubMed).

Alternatives for antigen "Nonstructural Protein 1", type "Antibodies"
Hosts (13)
Reactivities (13)
Applications (10), (3), (3), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (1)
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