Nonstructural Protein 2 antibody

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Immunogen NS2 antibody was raised against a synthetic peptide corresponding to 14 amino acids near the middle of the NS2 protein Efforts were made to use relatively conserved regions of the viral sequence as the antigen.
Blocking Peptide Blocking peptide for this product available: ABIN1004254
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Nonstructural Protein 2 (Nuclear Export Protein)
Background Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals, however, it is in birds that all subtypes, including the so-called “avian flu” or H5N1, can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. One of the less studied proteins encoded by the influenza virus is the nonstructural protein (NS) 2. NS2 binds to the influenza matrix protein M1 that is bound to the ribonucleoprotein (RNP) complex and mediates the contact between the M1/RNP complex and the cellular exportin CRM, but does not interact with nucleosomes.
Application Notes Avian Influenza Nonstructural Protein 2 antibody can be used for the detection of the Avian Influenza Nonstructural Protein 2 protein from influenza A in ELISA. Other applications are pending.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Garcia-Robles, Akarsu, Müller, Ruigrok, Baudin: "Interaction of influenza virus proteins with nucleosomes." in: Virology, Vol. 332, Issue 1, pp. 329-36, 2005 (PubMed).

Neumann, Hughes, Kawaoka: "Influenza A virus NS2 protein mediates vRNP nuclear export through NES-independent interaction with hCRM1." in: The EMBO journal, Vol. 19, Issue 24, pp. 6751-8, 2001 (PubMed).

Alexander: "A review of avian influenza in different bird species." in: Veterinary microbiology, Vol. 74, Issue 1-2, pp. 3-13, 2000 (PubMed).

Background publications Thompson, Shay, Weintraub, Brammer, Cox, Anderson, Fukuda: "Mortality associated with influenza and respiratory syncytial virus in the United States." in: JAMA, Vol. 289, Issue 2, pp. 179-86, 2003 (PubMed).

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