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Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) antibody

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Synonyms ARC, FCM, MYP, NOP, NOP30, B430311C09Rik, MYC, Nop30, Arc
Human, Mouse (Murine), Rat (Rattus)
(81), (32), (31)
(78), (3)
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
ELISA, Western Blotting (WB)
(66), (26), (15), (14), (11), (11), (7), (4), (3), (1)
Pubmed 2 references available
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Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 15 to 19 Business Days
Immunogen Rabbit polyclol Nop30 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human Nop30 (GenBank accession no. AAH12798).
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Nop30 (NOL3 Antibody Abstract)
Background Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and the caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. An alternate splicing isoform of ARC was identified as Nop30. While ARC interacts with caspase-2 and –8 and suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3, Nop30 multimerizes and binds to the splicing factor SRp30c and may act to influence alternative splice site selection in vivo. The Nop30 antibody will not detect ARC protein.
Application Notes Nop30 antibody can be used for detection of Nop30 by Western blot at 0.5 – 1 myg/ml. (Optimal dilution should be determined by user.) Mouse skeletal tissue lysate can be used as positive control. Antibody can also be used for ELISA and might be suited for other applications not tested so far. Nop30 antibody is human, mouse and rat reactive.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Stoss, Schwaiger, Cooper et al.: "Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c." in: The Journal of biological chemistry, Vol. 274, Issue 16, pp. 10951-62, 1999 (PubMed).

Koseki, Inohara, Chen et al.: "ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 9, pp. 5156-60, 1998 (PubMed).

Catalog No. ABIN1002926
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