P21-Activated Kinase 6 (PAK6) antibody

Details for Product No. ABIN1002959
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Antigen
Synonyms pak6, si:ch211-158b22.3, PAK5, 4732456M09
Reactivity
Human
(127), (40), (34), (8), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(129), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (6), (6), (5), (5), (5), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(94), (37), (34), (26), (24), (20), (13), (6), (5), (3), (2)
Pubmed 3 references available
Quantity 100 μg
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Immunogen PAK6 antibody was raised against a 13 amino acid peptide from near the center of human PAK6.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name p21-Activated Kinase 6 (PAK6 Antibody Abstract)
Background The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK6 was initially identified as an androgen receptor in a yeast two hybrid screen and was found to be highly expressed in testis and prostate tissues. Later experiments have shown it to be activated by MAP kinase kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.
Application Notes This antibody can be used for the detection of PAK6 by Western blot at 1 – 2 myg/ml. Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far. This antibody is human reactive.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Kaur, Liu, Gjoerup et al.: "Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase." in: The Journal of biological chemistry, Vol. 280, Issue 5, pp. 3323-30, 2005 (PubMed).

Jaffer, Chernoff: "p21-activated kinases: three more join the Pak." in: The international journal of biochemistry & cell biology, Vol. 34, Issue 7, pp. 713-7, 2002 (PubMed).

Yang, Li, Sharma et al.: "Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6." in: The Journal of biological chemistry, Vol. 276, Issue 18, pp. 15345-53, 2001 (PubMed).

Validation Images
Catalog No. ABIN1002959
452.54 $
Plus shipping costs $45.00
Quantity
Price
100 μg
452.54 $

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