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Plexin Domain Containing 2 (PLXDC2) (C-Term) antibody

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Synonyms MGC79122, TEM7R, 1200007L24Rik, 5430431D22Rik, AI646728, AU022916, AV231634, Tem7r
(11), (10), (3), (2), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(38), (22), (18)
(37), (2)
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
(36), (23), (16), (3), (2), (2), (2), (2)
Pubmed 4 references available
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Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 15 to 19 Business Days
Immunogen Plxdc2 antibody was raised in rabbits against a 17 amino acid peptide from near the carboxy terminus of human Plxdc2.
Blocking Peptide Blocking peptide for this product available: ABIN1003848
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Plxdc2 (PLXDC2 Antibody Abstract)
Background Plxdc2, also known as Tumor endothelial marker 7-related (TEM7R) encodes a protein with 57% amino acid identity to TEM7, the most abundant tumor endothelial marker. Plxdc2 is strongly expressed in the endothelial cells of the tumor stroma, but not in the endothelial cells of normal colonic tissue. Plxdc2 is also expressed at high levels in vessels of some normal tissues, with highest expression in muscle and lung. Plxdc2 and TEM7 may be important for tumor angiogenesis in humans. Cortactin was identified as a protein capable of binding to the extracellular region of both TEM7 and Plxdc2, and may provide new opportunities for the delivery of therapeutic and imaging agents to the vessels of solid tumors.
Application Notes Plxdc2 antibody can be used for detection of Plxdc2 by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Nanda, Buckhaults, Seaman et al.: "Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R." in: Cancer research, Vol. 64, Issue 23, pp. 8507-11, 2004 (PubMed).

Nanda, St Croix: "Tumor endothelial markers: new targets for cancer therapy." in: Current opinion in oncology, Vol. 16, Issue 1, pp. 44-9, 2003 (PubMed).

St Croix, Rago, Velculescu et al.: "Genes expressed in human tumor endothelium." in: Science (New York, N.Y.), Vol. 289, Issue 5482, pp. 1197-202, 2000 (PubMed).

Background publications Carson-Walter, Watkins, Nanda et al.: "Cell surface tumor endothelial markers are conserved in mice and humans." in: Cancer research, Vol. 61, Issue 18, pp. 6649-55, 2001 (PubMed).

Catalog No. ABIN1003027
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