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Details for Product No. ABIN1003032

Podoplanin (PDPN) antibody

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Antigen
Synonyms T1A, GP36, GP40, Gp38, OTS8, T1A-2, AGGRUS, HT1A-1, PA2.26, OTS-8, RANDAM-2, T1-alpha, T1a, T1alpha, E11, RTI40, PDPN
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Fluorescence Microscopy (FM), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN1003032
Quantity 100 µg
Price
455.93 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 7 Business Days
Immunogen Recombint ectodomain of human gp36 (Podoplanin)
Isotype IgG
Specificity This antibody will detect Prox-1 in the nucleus of lymphatic endothelial cells by immunostaining. Optimal dilutions should be determined by each laboratory for each application.
Purification Protein A affinity chromatography
Alternative Name Podoplanin
Background Produced from sera of rabbits immunized with the recombinant ectodomain of Podoplanin (gp36). Podoplanin is a highly O-glycosylated integral membrane protein that is specifically expressed in the endothelium of lymphatic capillaries but not in the blood vasculature. In normal skin and kidney, Podoplanin colocalized with VEGFR-3/FLT-4, another marker for lymphatic endothelial cells.
Application Notes Immunofluorescence: Use 1:750 to 1:1000 dilutions. Western Blotting: Use 1-5 µg/ml.
Restrictions For Research Use only
Format Liquid
Buffer PBS (pH 7.4) w/o preservative
Preservative Without preservative
Handling Advice Reconstituted antibody can also be aliquoted and stored at –20°C to –70°C for at least 6 months without detectable loss of activity.
Storage -20 °C
Product cited in: Breiteneder-Geleff, Matsui, Soleiman et al.: "Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis." in: The American journal of pathology, Vol. 151, Issue 4, pp. 1141-52, 1997 (PubMed).

Zimmer, Oeffner, Von Messling et al.: "Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium." in: The Biochemical journal, Vol. 341 ( Pt 2), pp. 277-84, 1999 (PubMed).

Schacht, Ramirez, Hong et al.: "T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema." in: The EMBO journal, Vol. 22, Issue 14, pp. 3546-56, 2003 (PubMed).

Alternatives for antigen "Podoplanin (PDPN)", type "Antibodies"
Hosts (66), (54), (15), (13), (5), (4), (1)
Reactivities (111), (43), (19), (2)
Applications (92), (51), (44), (35), (34), (27), (21), (20), (15), (11), (6), (3), (1)
Conjugates (9), (5), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Epitopes (12), (7), (6), (6), (3), (1), (1), (1)
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