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Receptor-Interacting serine-threonine Kinase 3 (RIPK3) antibody

Details for Product No. ABIN1003072
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Antigen
Synonyms RIP3, Hcyp2, 2610528K09Rik, AW107945, Rip3, RIPK3
Reactivity
Mouse (Murine), Rat (Rattus)
(78), (31), (18), (15), (14), (12), (12), (3)
Host
Rabbit
(90), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (6), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(80), (44), (34), (21), (10), (5), (3), (2), (1), (1)
Pubmed 3 references available
Quantity 100 µg
Shipping to United States (Change)
Availability Will be delivered in 6 to 7 Business Days
Catalog No. ABIN1003072
514.01 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Rabbit polyclol RIP3 antibody was raised against a peptide (AQFGRGRGWQPFHK) corresponding to amino acids 473 to 486 of murine RIP3 .
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Receptor Interacting Protein 3
Background Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Overexpression of RIP3 induces apoptosis and NF-kappaB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.
Application Notes RIP3 antibody can be used for detection of RIP3 by Western blot at 0.5 to 1 µg/ml. (Optimal dilution should be determined by user.) An approximately 57 kDa band can be detected. Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Yu, Huang, Shen et al.: "Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB." in: Current biology : CB, Vol. 9, Issue 10, pp. 539-42, 1999 (PubMed).

Sun, Lee, Navas et al.: "RIP3, a novel apoptosis-inducing kinase." in: The Journal of biological chemistry, Vol. 274, Issue 24, pp. 16871-5, 1999 (PubMed).

Pazdernik, Donner, Goebl et al.: "Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB." in: Molecular and cellular biology, Vol. 19, Issue 10, pp. 6500-8, 2000 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1003072
514.01 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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