DNA-Damage-Inducible Transcript 4 (DDIT4) (Internal Region) antibody

Details for Product No. ABIN1003101
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Antigen
Synonyms redd1, Dig2, REDD-1, REDD1, 5830413E08Rik, AA415483, Rtp801, dig2, rtp801, sb:cb821, zgc:64114
Epitope
Internal Region
(16), (15), (4), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(69), (31), (29), (12), (12)
Host
Rabbit
(67), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(56), (36), (25), (10), (9), (8), (5), (4), (3), (3), (2), (2)
Pubmed 4 references available
Quantity 100 μg
Shipping to United States (Change)
Availability Will be delivered in 6 to 7 Business Days
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Catalog No. ABIN1003101
514.01 $
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Immunogen RTP801 antibody was raised in rabbits against a 12 amino acid peptide from near the center of human RTP801.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name RTP801
Background RTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.
Application Notes RTP801 antibody can be used for the detection of RTP801 by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Shoshani, Faerman, Mett et al.: "Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis." in: Molecular and cellular biology, Vol. 22, Issue 7, pp. 2283-93, 2002 (PubMed).

Ellisen, Ramsayer, Johannessen et al.: "REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species." in: Molecular cell, Vol. 10, Issue 5, pp. 995-1005, 2002 (PubMed).

Wang, Malone, Thomenius et al.: "Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals." in: The Journal of biological chemistry, Vol. 278, Issue 29, pp. 27053-8, 2003 (PubMed).

Sofer, Lei, Johannessen et al.: "Regulation of mTOR and cell growth in response to energy stress by REDD1." in: Molecular and cellular biology, Vol. 25, Issue 14, pp. 5834-45, 2005 (PubMed).

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