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Endoglin (ENG) antibody

Details for Product No. ABIN1003125, Supplier: Login to see
Antigen
  • ENG
  • MGC137842
  • DKFZp469D0419
  • END
  • HHT1
  • ORW1
  • AI528660
  • AI662476
  • CD105
  • S-endoglin
Reactivity
Human
385
137
47
13
11
7
5
5
5
3
1
1
1
Host
Rabbit
233
186
66
4
2
1
Clonality
Polyclonal
Conjugate
Un-conjugated
52
50
36
19
7
6
5
4
4
4
4
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Flow Cytometry (FACS), ELISA, Western Blotting (WB)
275
275
119
102
86
49
42
41
26
14
12
11
9
7
6
3
3
3
3
2
2
2
2
2
1
1
1
1
Supplier
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Immunogen Recombint human soluble CD105/Endoglin
Isotype IgG
Purification Protein A affinity chromatography (+ His tag depleted)
Alternative Name sCD105 (Endoglin) (ENG Antibody Abstract)
Background Produced from sera of rabbits immunized with highly pure recombinant human soluble CD105/Endoglin produced in insect cells. The recombinant soluble CD105/Endoglin consists of amino acid 26 (Glu) to 586 (Leu) and is fused to a C-terminal His-tag (6xHis).
Pathways
Application Notes ELISA: Use at 1-15 µg/ml. Western Analysis: Use at a concentration of 1-2 µg/ml with the appropriate secondary reagents. FACS analysis and cell sorting: Use at 2-5 µg/ml together with the appropriate secondary reagents. Immunohistochemistry: Not investigated so far. Optimal dilutions should be determined by each laboratory for each application.
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized from PBS (pH 7.4) w/o preservative
Preservative Without preservative
Handling Advice The lyophilized IgG is stable at 4°C for at least six months and for greater than a year when kept at –20°C.
Storage -20 °C
Product cited in: Parker, Goldring, Philip: "Endoglin is expressed on human chondrocytes and forms a heteromeric complex with betaglycan in a ligand and type II TGFbeta receptor independent manner." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 18, Issue 2, pp. 289-302, 2003 (PubMed).

Fonsatti, Del Vecchio, Altomonte et al.: "Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies." in: Journal of cellular physiology, Vol. 188, Issue 1, pp. 1-7, 2001 (PubMed).

Arthur, Ure, Smith et al.: "Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development." in: Developmental biology, Vol. 217, Issue 1, pp. 42-53, 2000 (PubMed).

Barbara, Wrana, Letarte: "Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily." in: The Journal of biological chemistry, Vol. 274, Issue 2, pp. 584-94, 1999 (PubMed).

McAllister, Grogg, Johnson et al.: "Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1." in: Nature genetics, Vol. 8, Issue 4, pp. 345-51, 1995 (PubMed).

Cheifetz, Bellón, Calés et al.: "Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells." in: The Journal of biological chemistry, Vol. 267, Issue 27, pp. 19027-30, 1992 (PubMed).