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BCL2-Associated Athanogene 4 (BAG4) (N-Term) antibody

Details for Product No. ABIN1003136, Supplier: Log in to see
Antigen
  • BAG4
  • fd20a04
  • wu:fd20a04
  • si:dkey-220o5.3
  • ATBAG4
  • BCL-2-associated athanogene 4
  • BAG-4
  • SODD
  • 2410112I15Rik
Epitope
N-Term
29
21
16
11
10
7
4
2
2
2
2
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
107
31
28
3
1
1
1
Host
Rabbit
82
21
8
1
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
3
3
3
1
Application
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
104
50
12
12
7
5
3
2
1
1
1
1
Supplier
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Immunogen Rabbit polyclol SODD antibody was raised against a peptide corresponding to amino acids 2 to 16 of human SODD .
Blocking Peptide Blocking peptide for this product available: ABIN1004198
Isotype IgG
Purification Antibody is purified via DEAE-column chromatography.
Alternative Name Silencer of Death Domains (BAG4 Antibody Abstract)
Background Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domains . SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.
Application Notes SODD antibody can be used for detection of SODD by Western blot at 1:500 to 1:2000 dilution. (Optimal dilution should be determined by user.) An approximately 60 kDa band can be detected. Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Background publications Jiang, Woronicz, Liu et al.: "Prevention of constitutive TNF receptor 1 signaling by silencer of death domains." in: Science (New York, N.Y.), Vol. 283, Issue 5401, pp. 543-6, 1999 (PubMed).