SLIT and NTRK-Like Family, Member 1 (SLITRK1) (Internal Region) antibody

Details for Product No. ABIN1003146
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Synonyms DKFZp459G0529, LRRC12, TTM, 3200001I04Rik
Internal Region
(20), (7), (5), (3), (3), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(53), (29), (28), (2), (1), (1)
(43), (13)
(3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(34), (27), (15), (10), (10), (3), (3), (1), (1)
Pubmed 4 references available
Quantity 100 μg
Shipping to United States (Change)
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Catalog No. ABIN1003146
452.54 $
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Immunogen Slitrk1 antibody was raised in rabbits against an 18 amino acid peptide from near the center of human Slitrk1.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Slitrk1
Background SLIT and NTRK-like family 1 (Slitrk1) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette’s Syndrome, it is thought to play only a minor role if at all. This antibody is predicted to have no cross-reactivity to other Slitrk proteins.
Application Notes Slitrk1 antibody can be used for detection of Slitrk1 by Western blot at 1 – 2 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Fabbrini, Pasquini, Aurilia et al.: "A large Italian family with Gilles de la Tourette syndrome: clinical study and analysis of the SLITRK1 gene." in: Movement disorders : official journal of the Movement Disorder Society, Vol. 22, Issue 15, pp. 2229-34, 2007 (PubMed).

Abelson, Kwan, ORoak et al.: "Sequence variants in SLITRK1 are associated with Tourette's syndrome." in: Science (New York, N.Y.), Vol. 310, Issue 5746, pp. 317-20, 2005 (PubMed).

Aruga, Yokota, Mikoshiba: "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue." in: Gene, Vol. 315, pp. 87-94, 2003 (PubMed).

Aruga, Mikoshiba: "Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth." in: Molecular and cellular neurosciences, Vol. 24, Issue 1, pp. 117-29, 2003 (PubMed).

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