Survivin antibody (BIRC5) (N-Term)

Details for Product anti-BIRC5 Antibody No. ABIN1003225, Supplier: Log in to see
Antigen
  • bir5a
  • survivin
  • LOC398389
  • BIRC5
  • BIR1
  • Su2
  • Survivin
  • Survivin1
  • XBIR1
  • api4
  • epr-1
  • svv1
  • xSurvivin1
  • xsurv
  • SIX
  • Su1
  • svv2
  • birc5
  • xSurvivin
  • xSurvivin2
  • AAC-11
  • Api4
  • TIAP
  • survivin40
  • baculoviral IAP repeat-containing 5a
  • survivin
  • baculoviral IAP repeat-containing 5
  • baculoviral IAP repeat-containing 5, gene 1
  • baculoviral IAP repeat containing 5
  • birc5a
  • LOC398389
  • BIRC5
  • birc5.1
  • birc5.2
  • AaeL_AAEL012446
  • CpipJ_CPIJ001663
  • CpipJ_CPIJ002689
  • CpipJ_CPIJ006694
  • Birc5
Alternatives
anti-Cat (Feline) Survivin antibody for Chromatin Immunoprecipitation
Epitope
N-Term
65
26
23
19
18
16
15
15
12
7
7
6
5
5
5
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
429
167
163
35
20
19
12
4
2
2
1
Host
Rabbit
297
139
16
1
Clonality
Polyclonal
Conjugate
This Survivin antibody is un-conjugated
24
17
16
13
13
13
12
11
9
9
8
8
6
5
5
5
5
3
3
3
2
2
2
2
2
2
2
1
Application
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
348
206
182
158
148
127
107
33
33
26
7
5
3
3
3
3
2
2
2
2
1
1
1
Options
Supplier
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Immunogen Rabbit polyclol survivin antibody was raised against a peptide corresponding to amino acids 1 to 12 of human origin .
Blocking Peptide Blocking peptide for this product available: ABIN1004201
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Survivin (Inhibitor of Apoptosis) (BIRC5 Antibody Abstract)
Background Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP. Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.
Pathways Nuclear Hormone Receptor Binding
Application Notes Survivin antibody can be used for detection of survivin by Western blot at 0.5 to 1 µg/ml. (Optimal dilution should be determined by user.) An approximate 17 kDa band should be detected. Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Kobayashi, Hatano, Otaki, Ogasawara, Tokuhisa: "Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 4, pp. 1457-62, 1999 (PubMed).

Li, Ambrosini, Chu, Plescia, Tognin, Marchisio, Altieri: "Control of apoptosis and mitotic spindle checkpoint by survivin." in: Nature, Vol. 396, Issue 6711, pp. 580-4, 1999 (PubMed).

Ambrosini, Adida, Altieri: "A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma." in: Nature medicine, Vol. 3, Issue 8, pp. 917-21, 1997 (PubMed).

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