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Survivin (Inhibitor of Apoptosis) (C-Term) antibody

Details for Product No. ABIN1003227
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Antigen
Epitope
C-Term
(1), (1)
Reactivity
Mouse (Murine)
(2)
Host
Rabbit
(2)
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(2), (2), (2)
Pubmed 3 references available
Quantity 100 µg
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Catalog No. ABIN1003227
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Immunogen Rabbit polyclol Survivin antibody was raised against a synthetic peptide corresponding to amino acids near the carboxy terminus of mouse Survivin (GenBank Accession No. NP_033819).
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Background Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP. Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.
Application Notes mSurvivin antibody can be used for detection of survivin by Western blot at 1 to 2 µg/ml. (Optimal dilution should be determined by user.) An approximate 17 kDa band can be detected. Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Ambrosini, Adida, Altieri: "A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma." in: Nature medicine, Vol. 3, Issue 8, pp. 917-21, 1997 (PubMed).

Li, Ambrosini, Chu et al.: "Control of apoptosis and mitotic spindle checkpoint by survivin." in: Nature, Vol. 396, Issue 6711, pp. 580-4, 1999 (PubMed).

Kobayashi, Hatano, Otaki et al.: "Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 4, pp. 1457-62, 1999 (PubMed).

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