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RASD Family, Member 2 (RASD2) (C-Term) antibody

Details for Product No. ABIN1003257
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Antigen
Synonyms RASD2, MGC:4834, Rhes, TEM2, 4930526B11Rik, AU045414, TEM-2
Epitope
C-Term
(18), (10), (8), (7), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(70), (41), (40), (13), (1)
Host
Rabbit
(58), (12)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(60), (40), (15), (11), (10), (9), (6), (2), (1)
Pubmed 4 references available
Quantity 100 µg
Shipping to United States (Change)
Availability Will be delivered in 6 to 7 Business Days
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Catalog No. ABIN1003257
514.01 $
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Immunogen TEM2 antibody was raised in rabbits against a 15 amino acid peptide near the carboxy terminus of the human TEM2.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name TEM2
Background Rhes, also known as tumor endothelial marker 2 (TEM2), is a small GTP-binding protein that is predominantly expressed in the striatal region of the brain. This protein belongs to the RASD subfamily of Ras-related GTP-binding protein superfamily and is thought to play a role in the normal development and function of the brain as mice lacking this gene showed increased anxiety levels and motor coordination deficits. Rhes was identified as TEM2 through analysis of genes whose expression was upregulated in tumor endothelium. Tumor endothelial markers are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies.
Application Notes TEM2 antibody can be used for detection of TEM2 by Western blot at 1 – 2 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Carson-Walter, Watkins, Nanda et al.: "Cell surface tumor endothelial markers are conserved in mice and humans." in: Cancer research, Vol. 61, Issue 18, pp. 6649-55, 2001 (PubMed).

Vargiu, Morte, Manzano et al.: "Thyroid hormone regulation of rhes, a novel Ras homolog gene expressed in the striatum." in: Brain research. Molecular brain research, Vol. 94, Issue 1-2, pp. 1-8, 2001 (PubMed).

Yamamoto, Irie, Asada et al.: "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein." in: Oncogene, Vol. 23, Issue 22, pp. 3889-97, 2004 (PubMed).

Spano, Branchi, Rosica et al.: "Rhes is involved in striatal function." in: Molecular and cellular biology, Vol. 24, Issue 13, pp. 5788-96, 2004 (PubMed).

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