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rho Guanine Nucleotide Exchange Factor (GEF) 17 (ARHGEF17) (Internal Region) antibody

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Synonyms P164RHOGEF, TEM4, p164-RhoGEF, 8030463K16, AI428794, AW558066, BC035332, mKIAA0337
Internal Region
(6), (2), (1)
(17), (3), (1)
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(15), (13), (9), (6), (3), (2)
Pubmed 4 references available
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Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 15 to 19 Business Days
Immunogen TEM4 antibody was raised in rabbits against an 18 amino acid peptide near the center of human TEM4.
Blocking Peptide Blocking peptide for this product available: ABIN1003982
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name TEM4 (ARHGEF17 Antibody Abstract)
Background Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.
Application Notes TEM4 antibody can be used for detection of TEM4 by Western blot at 1 – 2 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Davies, Cunnick, Mansel et al.: "Levels of expression of endothelial markers specific to tumour-associated endothelial cells and their correlation with prognosis in patients with breast cancer." in: Clinical & experimental metastasis, Vol. 21, Issue 1, pp. 31-7, 2004 (PubMed).

Nanda, St Croix: "Tumor endothelial markers: new targets for cancer therapy." in: Current opinion in oncology, Vol. 16, Issue 1, pp. 44-9, 2003 (PubMed).

Rümenapp, Freichel-Blomquist, Wittinghofer et al.: "A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain." in: The Biochemical journal, Vol. 366, Issue Pt 3, pp. 721-8, 2002 (PubMed).

Background publications Carson-Walter, Watkins, Nanda et al.: "Cell surface tumor endothelial markers are conserved in mice and humans." in: Cancer research, Vol. 61, Issue 18, pp. 6649-55, 2001 (PubMed).

Catalog No. ABIN1003259
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