Plexin Domain Containing 1 (PLXDC1) (C-Term) antibody

Details for Product No. ABIN1003262
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Antigen
Synonyms PLXDC1, TEM3, TEM7, 2410003I07Rik, AI848450, Tem7, Arl12
Epitope
C-Term
(28), (15), (7), (4), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(85), (21), (21), (1), (1), (1), (1)
Host
Rabbit
(71), (14)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(70), (47), (34), (13), (4), (3), (3), (3), (2), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 6 to 7 Business Days
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Immunogen TEM7 antibody was raised in rabbits against a 16 amino acid peptide from near the carboxy terminus of human TEM7.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name TEM7 (PLXDC1 Antibody Abstract)
Background Tumor endothelial marker 7 (TEM7) was identified through serial analysis of gene expression on endothelial cells isolated from human normal and malignant colorectal tissues. Further experiments verified TEM7 was highly expressed in the endothelium of numerous other cancer types including breast, lung and brain tumors. At least four isoforms of TEM7 are known to exist, these include intracellular, secreted, and membrane-bound forms. A homologous protein, TEM7R (also known as PLXDC2), acts as a binding partner to TEM7 and is also abundantly expressed in the endothelium of malignant colorectal cancer but is absent or rare in normal colon mucosa. High expression of TEM7 is associated with metastasis and poor survival of patients with osteogenic sarcoma.
Application Notes TEM7 antibody can be used for detection of TEM7 by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Fuchs, Mahlum, Halder et al.: "High expression of tumor endothelial marker 7 is associated with metastasis and poor survival of patients with osteogenic sarcoma." in: Gene, Vol. 399, Issue 2, pp. 137-43, 2007 (PubMed).

Nanda, Buckhaults, Seaman et al.: "Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R." in: Cancer research, Vol. 64, Issue 23, pp. 8507-11, 2004 (PubMed).

Carson-Walter, Watkins, Nanda et al.: "Cell surface tumor endothelial markers are conserved in mice and humans." in: Cancer research, Vol. 61, Issue 18, pp. 6649-55, 2001 (PubMed).

St Croix, Rago, Velculescu et al.: "Genes expressed in human tumor endothelium." in: Science (New York, N.Y.), Vol. 289, Issue 5482, pp. 1197-202, 2000 (PubMed).

Validation Images
Catalog No. ABIN1003262
452.54 $
Plus shipping costs $45.00
Quantity
Price
100 μg
452.54 $

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