Plexin Domain Containing 1 (PLXDC1) (C-Term) antibody

Details for Product No. ABIN1003262
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Synonyms TEM3, TEM7, Arl12, Tem7, 2410003I07Rik, AI848450, PLXDC1
(11), (5), (4), (4), (3), (2), (2), (2), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(54), (25), (23), (1), (1)
(47), (10)
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(48), (33), (27), (15), (4), (2), (2), (1), (1)
Pubmed 4 references available
Catalog no. ABIN1003262
Quantity 100 µg
514.01 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 7 Business Days

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Immunogen TEM7 antibody was raised in rabbits against a 16 amino acid peptide from near the carboxy terminus of human TEM7.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name TEM7
Background Tumor endothelial marker 7 (TEM7) was identified through serial analysis of gene expression on endothelial cells isolated from human normal and malignant colorectal tissues. Further experiments verified TEM7 was highly expressed in the endothelium of numerous other cancer types including breast, lung and brain tumors. At least four isoforms of TEM7 are known to exist, these include intracellular, secreted, and membrane-bound forms. A homologous protein, TEM7R (also known as PLXDC2), acts as a binding partner to TEM7 and is also abundantly expressed in the endothelium of malignant colorectal cancer but is absent or rare in normal colon mucosa. High expression of TEM7 is associated with metastasis and poor survival of patients with osteogenic sarcoma.
Application Notes TEM7 antibody can be used for detection of TEM7 by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: St Croix, Rago, Velculescu et al.: "Genes expressed in human tumor endothelium." in: Science (New York, N.Y.), Vol. 289, Issue 5482, pp. 1197-202, 2000 (PubMed).

Carson-Walter, Watkins, Nanda et al.: "Cell surface tumor endothelial markers are conserved in mice and humans." in: Cancer research, Vol. 61, Issue 18, pp. 6649-55, 2001 (PubMed).

Nanda, Buckhaults, Seaman et al.: "Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R." in: Cancer research, Vol. 64, Issue 23, pp. 8507-11, 2004 (PubMed).

Fuchs, Mahlum, Halder et al.: "High expression of tumor endothelial marker 7 is associated with metastasis and poor survival of patients with osteogenic sarcoma." in: Gene, Vol. 399, Issue 2, pp. 137-43, 2007 (PubMed).

Hosts (47), (10)
Reactivities (54), (25), (23), (1), (1)
Applications (48), (33), (27), (15), (4), (2), (2), (1), (1)
Epitopes (11), (5), (4), (4), (3), (2), (2), (2), (1), (1), (1)
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