Tetratricopeptide Repeat Containing Protein 5 antibody

Details for Product No. ABIN1003264
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Antigen
Reactivity
Human, Mouse (Murine)
Host
Rabbit
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Quantity 100 μg
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Catalog No. ABIN1003264
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Immunogen Rabbit polyclol TTC5 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human TTC5 (Genbank accession No. Q8N0Z6).
Isotype IgG
Purification Immunoaffinity chromatography purified IgG.
Background Tetratricopeptide repeat protein 5 (TTC5) is a member of a diverse group of functionally distinct proteins that are characterized by containing one or more tetratricopeptide repeats. Each motif consists of two anti-parallel a-helices such that tandem arrays of TPR motifs generate a right-handed helical structure with an amphipathic channel that may serve to accommodate the complementary region of a target protein. While the exact function of TTC5 remains unclear, it is thought that the TPR motifs serve to mediate protein-protein interactions such as those seen with protein chaperones HSP70 and HSP90 and some proteins involved in cell stress response signaling pathways such as protein phosphatase 5, suggesting that TTC5 may also function via protein-protein interactions mediated by its TPR motifs.
Application Notes TTC5 antibody can be used for the detection of TTC5 by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Blatch, Lässle: "The tetratricopeptide repeat: a structural motif mediating protein-protein interactions." in: BioEssays : news and reviews in molecular, cellular and developmental biology, Vol. 21, Issue 11, pp. 932-9, 1999 (PubMed).

Yang, Roe, Cliff et al.: "Molecular basis for TPR domain-mediated regulation of protein phosphatase 5." in: The EMBO journal, Vol. 24, Issue 1, pp. 1-10, 2005 (PubMed).

Song, Masison: "Independent regulation of Hsp70 and Hsp90 chaperones by Hsp70/Hsp90-organizing protein Sti1 (Hop1)." in: The Journal of biological chemistry, Vol. 280, Issue 40, pp. 34178-85, 2005 (PubMed).

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