IL-27 (N-Term) antibody

Details for Product No. ABIN1003282
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Antigen
Synonyms EUROIMAGE1875335, IL25, IL27, IL27w, R33729_1, SF20, EBI-3, IL-27
Epitope
N-Term
(6), (4), (2), (1)
Reactivity
Human, Mouse (Murine)
(27), (15)
Host
Rabbit
(15), (8)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (1)
Application
ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
(16), (15), (7), (5), (2), (1), (1)
Pubmed 3 references available
Quantity 100 µg
Shipping to United States (Change)
Availability Will be delivered in 6 to 7 Business Days
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Catalog No. ABIN1003282
514.01 $
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Immunogen IL-27 antibody was raised against a 16 amino acid peptide from near the amino terminus of human IL-27.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Background Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet.
Application Notes This antibody can be used for the detection of IL-27 by Western blot at 2 - 4 myg/ml. Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far. This antibody is human and mouse reactive.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Pflanz, Hibbert, Mattson et al.: "WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 4, pp. 2225-31, 2004 (PubMed).

Hisada, Kamiya, Fujita et al.: "Potent antitumor activity of interleukin-27." in: Cancer research, Vol. 64, Issue 3, pp. 1152-6, 2004 (PubMed).

Hunter: "New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions." in: Nature reviews. Immunology, Vol. 5, Issue 7, pp. 521-31, 2005 (PubMed).

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