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TIRAP antibody (Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein) (Internal Region)

Details for Product anti-TIRAP Antibody No. ABIN1003283, Supplier: Log in to see
Antigen
  • AA407980
  • BACTS1
  • C130027E04Rik
  • mal
  • Mal
  • MyD88-2
  • Tlr4ap
  • Wyatt
  • wyatt
Alternatives
anti-Human TIRAP antibody for Western Blotting
Epitope
Internal Region
36
19
17
6
5
4
3
3
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
135
65
34
Host
Rabbit
110
29
5
3
Clonality
Polyclonal
Conjugate
This TIRAP antibody is un-conjugated
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
110
55
42
28
22
7
4
3
2
2
1
Supplier
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Immunogen Rabbit polyclol TIRAP antibody was raised against a peptide corresponding to amino acids near the middle of human TIRAP (GenBank accession no. AAL05627).
Blocking Peptide Blocking peptide for this product available: ABIN1004041
Isotype IgG
Purification Ion exchange chromatography purified.
Alternative Name TIRAP (Toll-Like Receptor Adaptor Protein) (TIRAP Antibody Abstract)
Background Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-kappaB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling.
Pathways TLR Signaling
Application Notes TIRAP antibody can be used for detection of TIRAP by Western blot at 4 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Background publications Vogel, Fitzgerald, Fenton: "TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression." in: Molecular interventions, Vol. 3, Issue 8, pp. 466-77, 2004 (PubMed).

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).

Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002 (PubMed).

Product cited in: ONeill, Fitzgerald, Bowie: "The Toll-IL-1 receptor adaptor family grows to five members." in: Trends in immunology, Vol. 24, Issue 6, pp. 286-90, 2003 (PubMed).