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TNF Receptor-Associated Factor 2 (TRAF2) (N-Term) antibody

Details for Product No. ABIN1003294
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Antigen
Synonyms MGC:45012, TRAP, TRAP3, TANK, AI325259
Epitope
N-Term
(23), (11), (7), (6), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(96), (44), (37), (4)
Host
Rabbit
(74), (20), (6), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(87), (44), (29), (24), (15), (10), (8), (7), (5), (4), (2)
Pubmed 4 references available
Quantity 100 µg
Shipping to United States (Change)
Availability Will be delivered in 6 to 7 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1003294
514.01 $
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Immunogen Rabbit polyclol TRAF2 antibody was raised against a 16 amino acid peptide from near the amino terminus of human TRAF2 (Genbank accession No. CAI15106).
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name TNF Receptor Associated Factor 2
Background Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappaB activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-b receptor (LTbR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.
Application Notes TRAF2 antibody can be used for the detection of TRAF2 by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Arch, Gedrich, Thompson: "Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death." in: Genes & development, Vol. 12, Issue 18, pp. 2821-30, 1998 (PubMed).

van Kooten, Banchereau: "CD40-CD40 ligand." in: Journal of leukocyte biology, Vol. 67, Issue 1, pp. 2-17, 2000 (PubMed).

Grech, Amesbury, Chan et al.: "TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells." in: Immunity, Vol. 21, Issue 5, pp. 629-42, 2004 (PubMed).

Davies, Mak, Young et al.: "TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells." in: Molecular and cellular biology, Vol. 25, Issue 22, pp. 9806-19, 2005 (PubMed).

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