TNF-Like 1A (DR3 Ligand) (N-Term) antibody

Details for Product No. ABIN1003303, Supplier: Log in to see
Human, Mouse (Murine), Rat (Rattus)
ELISA, Western Blotting (WB)
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Immunogen Rabbit polyclol TL1A antibody was raised against a peptide corresponding to 14 amino acids near the N-terminus of human TL1A (GenBank accession no. AAM77366).
Blocking Peptide Blocking peptide for this product available: ABIN1004212
Isotype IgG
Purification Ion exchange chromatography purified.
Background Members in the TNF and its receptor superfamilies regulate immune responses and induce apoptosis. DR3 (also termed Wsl-1, Apo-3, TRAMP, and LARD) is preferentially expressed by T lymphocytes and upregulated during T cell activation. The ligand for DR3 was recently identified and designated TL1A. TL1A also binds decoy receptor DcR3/TR6, which is expressed in several lung and colon carcinomas and in some normal tissues. TL1A induces apoptosis and NF-kappaB activation in DR3 expressing cells, which is antagonized by DcR3. TL1A is upregulated by proinflammatory cytokines TNF and IL-1. TL1A is a longer variant of TL1 (also called VEGI).
Application Notes TL1A antibody can be used for detection of TL1A by Western blot at 0.5 to 1 µg/ml. (Optimal dilution should be determined by user.) This polyclonal antibody will not cross-react with TL1. Antibody can also be used for ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Bodmer, Burns, Schneider, Hofmann, Steiner, Thome, Bornand, Hahne, Schröter, Becker, Wilson, French, Browning, MacDonald, Tschopp: "TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)." in: Immunity, Vol. 6, Issue 1, pp. 79-88, 1997 (PubMed).

Screaton, Xu, Olsen, Cowper, Tan, McMichael, Bell: "LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 9, pp. 4615-9, 1997 (PubMed).

Background publications Chinnaiyan, ORourke, Yu, Lyons, Garg, Duan, Xing, Gentz, Ni, Dixit: "Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95." in: Science (New York, N.Y.), Vol. 274, Issue 5289, pp. 990-2, 1996 (PubMed).

Kitson, Raven, Jiang, Goeddel, Giles, Pun, Grinham, Brown, Farrow: "A death-domain-containing receptor that mediates apoptosis." in: Nature, Vol. 384, Issue 6607, pp. 372-5, 1996 (PubMed).

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