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TOLLIP antibody (Toll Interacting Protein) (Internal Region)

Details for Product anti-TOLLIP Antibody No. ABIN1003313, Supplier: Log in to see
Antigen
  • 4930403G24Rik
  • 4931428G15Rik
  • fk22a02
  • GB17961
  • IL-1RAcPIP
  • im:7145391
  • TOLLIP
  • tollip
  • wu:fk22a02
  • zgc:76985
Epitope
Internal Region
32
24
13
12
6
6
6
5
3
2
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
152
50
33
2
2
2
2
1
Host
Rabbit
95
63
6
Clonality
Polyclonal
Conjugate
This TOLLIP antibody is un-conjugated
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
150
72
42
22
19
16
15
14
6
5
4
Supplier
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Immunogen Rabbit polyclol TOLLIP antibody was raised against a 16 amino acid peptide from near the center of human TOLLIP (Genbank accession No. P60484).
Blocking Peptide Blocking peptide for this product available: ABIN1004050
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Toll Interacting Protein (TOLLIP Antibody Abstract)
Background Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.
Application Notes TOLLIP antibody can be used for the detection of TOLLIP by Western blot at 1 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: McGettrick, ONeill: "The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction." in: Molecular immunology, Vol. 41, Issue 6-7, pp. 577-82, 2004 (PubMed).

Background publications Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).

Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002 (PubMed).

Zhang, Ghosh: "Negative regulation of toll-like receptor-mediated signaling by Tollip." in: The Journal of biological chemistry, Vol. 277, Issue 9, pp. 7059-65, 2002 (PubMed).