Toll Interacting Protein (TOLLIP) (Internal Region) antibody

Details for Product No. ABIN1003313
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Antigen
Synonyms IL-1RAcPIP, TOLLIP, GB17961, 4930403G24Rik, 4931428G15Rik, fk22a02, im:7145391, wu:fk22a02, zgc:76985, tollip
Epitope
Internal Region
(21), (11), (7), (6), (5), (3), (3), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(98), (52), (41), (4), (4), (4), (1)
Host
Rabbit
(75), (29), (4)
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
(98), (48), (26), (25), (12), (12), (7), (5), (4), (3)
Pubmed 4 references available
Quantity 100 μg
Shipping to United States (Change)
Availability Will be delivered in 6 to 7 Business Days
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Catalog No. ABIN1003313
514.01 $
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Immunogen Rabbit polyclol TOLLIP antibody was raised against a 16 amino acid peptide from near the center of human TOLLIP (Genbank accession No. P60484).
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Toll Interacting Protein
Background Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.
Application Notes TOLLIP antibody can be used for the detection of TOLLIP by Western blot at 1 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Zhang, Ghosh: "Negative regulation of toll-like receptor-mediated signaling by Tollip." in: The Journal of biological chemistry, Vol. 277, Issue 9, pp. 7059-65, 2002 (PubMed).

Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002 (PubMed).

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).

McGettrick, ONeill: "The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction." in: Molecular immunology, Vol. 41, Issue 6-7, pp. 577-82, 2004 (PubMed).

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