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TLR1 antibody (Toll-Like Receptor 1) (Internal Region)

Details for Product anti-TLR1 Antibody No. ABIN1003316, Supplier: Log in to see
Antigen
  • CD281
  • rsc786
  • TIL
  • TIL. LPRS5
Alternatives
anti-Human TLR1 antibody for Flow Cytometry
Epitope
Internal Region
31
20
6
5
5
5
3
2
2
2
2
2
1
1
1
1
1
Reactivity
Human
157
73
26
Host
Rabbit
122
46
10
5
Clonality
Polyclonal
Conjugate
This TLR1 antibody is un-conjugated
15
14
14
4
3
3
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
108
59
55
48
32
18
15
14
11
8
7
5
3
1
1
Supplier
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Immunogen Rabbit polyclol TLR1 antibody was raised against a peptide corresponding to 17 amino acids near the center of human TLR1 (GenBank accession no. AAB94569).
Blocking Peptide Blocking peptide for this product available: ABIN1004042
Isotype IgG
Purification Ion exchange chromatography purified.
Alternative Name Toll-Like Receptor 1 (TLR1 Antibody Abstract)
Background Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR1 is co-expressed with TLR2 on myeloid cells of the innate immune systems in lymphoid tissue such as monocytes and dendritic cells where they form heterodimers that can recognize triacylated lipoproteins.
Pathways TLR Signaling
Application Notes TLR1 antibody can be used for detection of TLR1 by Western blot at 1 to 2 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Background publications Vogel, Fitzgerald, Fenton: "TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression." in: Molecular interventions, Vol. 3, Issue 8, pp. 466-77, 2004

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003

Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002

Product cited in: ONeill, Fitzgerald, Bowie: "The Toll-IL-1 receptor adaptor family grows to five members." in: Trends in immunology, Vol. 24, Issue 6, pp. 286-90, 2003