Toll-Like Receptor 1 (TLR1) (Internal Region) antibody

Details for Product No. ABIN1003316
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Antigen
Synonyms CD281, TIL, TIL. LPRS5, rsc786
Epitope
Internal Region
(22), (4), (3), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(111), (52), (22), (17), (17)
Host
Rabbit
(79), (33), (5), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (8), (6), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
(70), (57), (34), (26), (21), (21), (11), (10), (8), (3), (2), (2), (1), (1)
Pubmed 4 references available
Catalog no. ABIN1003316
Quantity 100 µg
Price
514.01 $   Plus shipping costs $45.00
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Immunogen Rabbit polyclol TLR1 antibody was raised against a peptide corresponding to 17 amino acids near the center of human TLR1 (GenBank accession no. AAB94569).
Isotype IgG
Purification Ion exchange chromatography purified.
Alternative Name Toll-Like Receptor 1
Background Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR1 is co-expressed with TLR2 on myeloid cells of the innate immune systems in lymphoid tissue such as monocytes and dendritic cells where they form heterodimers that can recognize triacylated lipoproteins.
Application Notes TLR1 antibody can be used for detection of TLR1 by Western blot at 1 to 2 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002 (PubMed).

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).

ONeill, Fitzgerald, Bowie: "The Toll-IL-1 receptor adaptor family grows to five members." in: Trends in immunology, Vol. 24, Issue 6, pp. 286-90, 2003 (PubMed).

Vogel, Fitzgerald, Fenton: "TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression." in: Molecular interventions, Vol. 3, Issue 8, pp. 466-77, 2004 (PubMed).

Hosts (79), (33), (5), (5)
Reactivities (111), (52), (22), (17), (17)
Applications (70), (57), (34), (26), (21), (21), (11), (10), (8), (3), (2), (2), (1), (1)
Conjugates (8), (8), (6), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (22), (4), (3), (3), (2), (2), (2), (1), (1), (1)
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