Toll-Like Receptor 10 (TLR10) (Internal Region) antibody

Details for Product No. ABIN1003318
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Antigen
Synonyms CD290, TLR10
Epitope
Internal Region
(6), (3), (3), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(43), (5), (4), (2)
Host
Rabbit
(40), (9), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1)
Application
ELISA, Western Blotting (WB)
(40), (15), (11), (5), (5), (3), (2), (2), (2), (1)
Pubmed 4 references available
Catalog no. ABIN1003318
Quantity 100 µg
Price
514.01 $   Plus shipping costs $45.00
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Immunogen Rabbit polyclol TLR10 antibody was raised against a peptide corresponding to 14 amino acids near the middle of human TLR10 (GenBank accession no. AAQ88667).
Isotype IgG
Purification Ion exchange chromatography purified.
Alternative Name Toll-Like Receptor 10
Background Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR10 is highly homologous to TLRs 1 and 6 and is most highly expressed in lymphoid tissues. Most recently genetic variation in TLR10 has been associated with contributing to asthma risk. It should be noted that TLR10 exists in mice only as a pseudogene.
Application Notes TLR10 antibody can be used for detection of TLR10 by Western blot at 0.5 to 1 µg/ml. (Optimal dilution should be determined by user.) Despite its predicted size of ~90 kDa, a band correpsonding to TLR10 is observed at ~75 kDa in immunoblot assays. Antibody can also be used for ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002 (PubMed).

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).

ONeill, Fitzgerald, Bowie: "The Toll-IL-1 receptor adaptor family grows to five members." in: Trends in immunology, Vol. 24, Issue 6, pp. 286-90, 2003 (PubMed).

Vogel, Fitzgerald, Fenton: "TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression." in: Molecular interventions, Vol. 3, Issue 8, pp. 466-77, 2004 (PubMed).

Hosts (40), (9), (1)
Reactivities (43), (5), (4), (2)
Applications (40), (15), (11), (5), (5), (3), (2), (2), (2), (1)
Conjugates (1), (1), (1)
Epitopes (6), (3), (3), (1), (1), (1), (1), (1), (1)
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