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Toll-Like Receptor 3 (TLR3) (N-Term) antibody

Details for Product No. ABIN1003327
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Antigen
Synonyms CD283, IIAE2, AI957183, zgc:123006
Epitope
N-Term
(26), (19), (5), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(173), (112), (62), (45), (12), (4), (1), (1), (1)
Host
Rabbit
(112), (86), (7), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(24), (11), (9), (9), (9), (8), (4), (3), (3), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
(134), (86), (65), (51), (39), (26), (19), (15), (15), (10), (5), (1), (1)
Pubmed 4 references available
Quantity 100 µg
Shipping to United States (Change)
Availability Will be delivered in 6 to 7 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1003327
514.01 $
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Immunogen Rabbit polyclol TLR3 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human TLR3 (GenBank accession no. O15455).
Isotype IgG
Purification Ion exchange chromatography purified.
Alternative Name Toll-Like Receptor 3
Background Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR3 is known to recognize viral double-stranded (ds) RNA, a molecular pattern associated with viral infection. Recently it has been shown to recognize viruses such as Influenza A and West Nile Virus and can mediate entry of at least West Nile Virus.
Application Notes TLR3 antibody can be used for detection of TLR3 by Western blot at 1 to 2 µg/ml. (Optimal dilution should be determined by user.) K562 cell lysate can be used as a positive control. Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far. TLR3 antibody is human and mouse reactive.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Alexopoulou, Holt, Medzhitov et al.: "Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3." in: Nature, Vol. 413, Issue 6857, pp. 732-8, 2001 (PubMed).

Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002 (PubMed).

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).

McGettrick, ONeill: "The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction." in: Molecular immunology, Vol. 41, Issue 6-7, pp. 577-82, 2004 (PubMed).

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