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Toll-Like Receptor 3 (TLR3) (N-Term) antibody

Details for Product No. ABIN1003327, Supplier: Log in to see
Antigen
  • CD283
  • IIAE2
  • AI957183
  • zgc:123006
Alternatives
anti-Human Toll-Like Receptor 3 antibody for Immunohistochemistry (Frozen Sections)
Epitope
N-Term
41
29
13
13
5
5
5
5
5
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
210
139
48
19
3
1
1
1
1
Host
Rabbit
175
98
15
3
2
Clonality
Polyclonal
Conjugate
Un-conjugated
29
24
20
10
7
6
5
5
4
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
172
98
89
55
52
26
26
24
14
11
9
6
5
4
1
1
Supplier
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Immunogen Rabbit polyclol TLR3 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human TLR3 (GenBank accession no. O15455).
Blocking Peptide Blocking peptide for this product available: ABIN1004215
Isotype IgG
Purification Ion exchange chromatography purified.
Alternative Name Toll-Like Receptor 3 (TLR3 Antibody Abstract)
Background Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR3 is known to recognize viral double-stranded (ds) RNA, a molecular pattern associated with viral infection. Recently it has been shown to recognize viruses such as Influenza A and West Nile Virus and can mediate entry of at least West Nile Virus.
Pathways TLR Signaling
Application Notes TLR3 antibody can be used for detection of TLR3 by Western blot at 1 to 2 µg/ml. (Optimal dilution should be determined by user.) K562 cell lysate can be used as a positive control. Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far. TLR3 antibody is human and mouse reactive.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: McGettrick, ONeill: "The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction." in: Molecular immunology, Vol. 41, Issue 6-7, pp. 577-82, 2004 (PubMed).

Background publications Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).

Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002 (PubMed).

Alexopoulou, Holt, Medzhitov et al.: "Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3." in: Nature, Vol. 413, Issue 6857, pp. 732-8, 2001 (PubMed).