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Details for Product No. ABIN1003332

Toll-Like Receptor 5 (TLR5) (Internal Region) antibody

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Antigen
Synonyms SLEB1, TIL3, TLR-5, sleb1, til3, tlr-5
Epitope
»Alternatives Internal Region
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN1003332
Quantity 100 µg
Price
514.01 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 6 to 7 Business Days
Immunogen Rabbit polyclol TLR5 antibody was raised against a peptide corresponding to 16 amino acids near the center of human TLR5 (GenBank accession no. NP_003259).
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Toll-Like Receptor 5
Background Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR5 recognizes flagellin from both Gram-positive and Gram-negative bacteria and will cause the activation of NF-kappaB, leading to the activation of TNF-alpha and other cytokines. A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires’ disease and demonstrates the importance of TLR5 in the innate immune response.
Application Notes TLR5 antibody can be used for detection of TLR5 by Western blot at 1 to 2 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Hayashi, Smith, Ozinsky et al.: "The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5." in: Nature, Vol. 410, Issue 6832, pp. 1099-103, 2001 (PubMed).

Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002 (PubMed).

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).

McGettrick, ONeill: "The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction." in: Molecular immunology, Vol. 41, Issue 6-7, pp. 577-82, 2004 (PubMed).

Alternatives for antigen "Toll-Like Receptor 5 (TLR5)", type "Antibodies"
Hosts (95), (28), (6)
Reactivities (121), (67), (34), (7), (1), (1), (1), (1), (1), (1)
Applications (100), (47), (35), (24), (22), (18), (10), (10), (2), (2), (2), (1), (1), (1)
Conjugates (9), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (22), (9), (8), (6), (5), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1)
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