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Toll-Like Receptor 7 (TLR7) (Internal Region) antibody

Details for Product No. ABIN1003337, Supplier: Log in to see
Antigen
  • TLR7A
  • TLR7-like
  • RGD1563357
Alternatives
anti-Human Toll-Like Receptor 7 antibody for Enzyme Immunoassay
Epitope
Internal Region
34
18
13
13
12
10
6
6
6
6
6
5
5
5
5
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
182
84
30
3
3
2
2
1
1
1
1
Host
Rabbit
172
33
2
1
Clonality
Polyclonal
Conjugate
Un-conjugated
13
11
8
7
6
6
1
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
150
78
48
32
29
11
11
10
6
6
1
1
1
Supplier
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Immunogen Rabbit polyclol TLR7 antibody was raised against a peptide corresponding to 14 amino acids near the middle of mouse TLR7 (GenBank accession no. NP_573474).
Blocking Peptide Blocking peptide for this product available: ABIN1004047
Isotype IgG
Purification Ion exchange chromatography purified.
Alternative Name Toll-Like Receptor 7 (TLR7 Antibody Abstract)
Background Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR7, like TLRs 3, 8, and 9, is localized in intracellular acidic compartments such as the phagolysosome and will recognize some single-stranded RNA viruses such as vesicular stomatitis virus (VSV) and influenza virus. Activation of TLR7 by VSV results in stimulation of the immune response including IFNAlpha secretion, suggesting the importance of TLR7 in virus recognition.
Pathways TLR Signaling
Application Notes TLR7 antibody can be used for detection of TLR7 by Western blot at 0.5 to 2 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: ONeill, Fitzgerald, Bowie: "The Toll-IL-1 receptor adaptor family grows to five members." in: Trends in immunology, Vol. 24, Issue 6, pp. 286-90, 2003 (PubMed).

Background publications Vogel, Fitzgerald, Fenton: "TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression." in: Molecular interventions, Vol. 3, Issue 8, pp. 466-77, 2004 (PubMed).

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).

Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002 (PubMed).