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Toll-Like Receptor 8 (TLR8) (Internal Region) antibody

Details for Product No. ABIN1003340, Supplier: Login to see
Antigen
  • CD288
Alternatives
anti-Human Toll-Like Receptor 8 antibody for Western Blotting
Epitope
Internal Region
43
23
21
18
15
14
10
5
5
4
3
3
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine)
192
76
35
Host
Rabbit
164
45
10
2
Clonality
Polyclonal
Conjugate
Un-conjugated
17
15
13
8
8
7
5
5
4
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
139
89
74
43
27
13
11
10
7
4
4
Supplier
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Immunogen Rabbit polyclol TLR8 antibody was raised against a peptide corresponding to 16 amino acids near the middle of human TLR8 (GenBank accession no. NP_619542).
Blocking Peptide Blocking peptide for this product available: ABIN1004048
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Toll-Like Receptor 8 (TLR8 Antibody Abstract)
Background Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Like TLR7, TLR8 is localized to endosomal or lysosomal compartments and stimulates the innate immune response after activation by guanosine- and uridine-rich single-stranded RNA. Human but not murine TLR8 confers responsiveness to the antiviral compound R-848.
Pathways TLR Signaling
Application Notes TLR8 antibody can be used for detection of TLR8 by Western blot at 0.5 to 2 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: ONeill, Fitzgerald, Bowie: "The Toll-IL-1 receptor adaptor family grows to five members." in: Trends in immunology, Vol. 24, Issue 6, pp. 286-90, 2003 (PubMed).

Background publications Vogel, Fitzgerald, Fenton: "TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression." in: Molecular interventions, Vol. 3, Issue 8, pp. 466-77, 2004 (PubMed).

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).

Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002 (PubMed).